Weisinger R S, Denton D A, McKinley M J, Muller A F, Tarjan E
Am J Physiol. 1986 Oct;251(4 Pt 2):R690-9. doi: 10.1152/ajpregu.1986.251.4.R690.
The effect of both intravenous (iv; 24 micrograms/h) and intracerebroventricular (ivt; 3.8 micrograms/h) infusion over 1-2 days of angiotensin II (ANG II) on Na intake of both Na-replete and -deplete sheep (i.e., 22 h loss of parotid saliva) was observed. In Na-replete sheep with continuous access to water and 2-h daily access to 0.5 M NaCl solution, both iv and ivt ANG II caused an increase in Na intake. The increase in Na intake caused by iv or ivt ANG II was preceded by a Na deficit due to increased urinary Na excretion. The increase in Na intake was eliminated by the continuous return of urine. In Na-deplete sheep with continuous access to water and 2-h daily access to 0.6 M NaHCO3 solution, iv ANG II caused no change in Na loss but a small increase in Na intake during the 1st day of infusion. The ivt ANG II caused no change in Na loss or in Na intake. The iv ANG II caused a small and inconsistent increase in water intake in Na-replete sheep but did not cause any change in water intake of Na-deplete sheep. The ivt ANG II caused a large increase in water intake in both Na-replete and -deplete sheep. In both Na-replete and -deplete sheep, iv ANG II did not alter cerebrospinal fluid or plasma [Na] or osmolality but decreased plasma [K]. The ivt ANG II decreased both cerebrospinal fluid and plasma [Na] and osmolality. The results of the present experiments are consistent with the proposition that the ANG II-induced Na appetite in sheep is largely due to an ANG II-induced Na loss preceding the development of appetite.
观察了静脉输注（iv；24微克/小时）和脑室内输注（ivt；3.8微克/小时）血管紧张素II（ANG II）1 - 2天对钠充足和钠缺乏绵羊（即腮腺唾液22小时流失）钠摄入量的影响。在能持续饮水且每天有2小时可获取0.5 M NaCl溶液的钠充足绵羊中，静脉输注和脑室内输注ANG II均导致钠摄入量增加。静脉输注或脑室内输注ANG II导致的钠摄入量增加之前，因尿钠排泄增加出现了钠缺乏。持续回输尿液可消除钠摄入量的增加。在能持续饮水且每天有2小时可获取0.6 M NaHCO₃溶液的钠缺乏绵羊中，静脉输注ANG II在输注第1天对钠流失无影响，但钠摄入量有小幅增加。脑室内输注ANG II对钠流失和钠摄入量均无影响。静脉输注ANG II使钠充足绵羊的饮水量有小幅且不一致的增加，但对钠缺乏绵羊的饮水量无任何影响。脑室内输注ANG II使钠充足和钠缺乏绵羊的饮水量均大幅增加。在钠充足和钠缺乏绵羊中，静脉输注ANG II均未改变脑脊液或血浆中的[Na]或渗透压，但降低了血浆[K]。脑室内输注ANG II降低了脑脊液和血浆中的[Na]及渗透压。本实验结果与以下观点一致：绵羊中ANG II诱导的钠食欲很大程度上是由于食欲形成之前ANG II诱导的钠流失。
