Xu Linxin, Cui Junfang, Li Mina, Wu Qianqian, Liu Ming, Xu Minggang, Shi Guoliang, Yin Jianhong, Yang Jing
First Clinical Medical College, Shanxi Medical University, Taiyuan, People's Republic of China.
Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, Shanxi, 030001, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Jun 18;15:1877-1884. doi: 10.2147/DMSO.S361808. eCollection 2022.
To explore the association between serum asprosin and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM) in the community.
In this cross-sectional study, we retrospectively collected the clinical data of T2DM patients from a community health service center in southeastern Shanxi Province between November 2019 and July 2021. Logistic regression analysis was used to calculate the odds ratio (OR) and the 95% confidence interval (95% CI) of asprosin levels on the risk of DN.
Among 498 T2DM patients included in this study, 221 had microalbuminuria, 105 had massive albuminuria, and 172 did not have any signs of nephropathy. Serum asprosin level was positively correlated with diastolic blood pressure, body mass index, triglycerides, aspartate aminotransferase, alanine aminotransferase, creatinine, ACR and albumin-to-creatinine ratio (all P < 0.05) and negatively correlated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, HbA1c and estimated glomerular filtration rate (all P < 0.05). After adjusting for covariates, increased asprosin was associated with diabetic nephropathy (all OR = 2.560, 95% CI: 1.1592-4.116; P < 0.001).
The risk of DN significantly increases with serum asprosin levels, especially among female patients.
探讨社区2型糖尿病（T2DM）患者血清阿朴脂蛋白与糖尿病肾病（DN）之间的关联。
在这项横断面研究中，我们回顾性收集了2019年11月至2021年7月期间山西省东南部某社区卫生服务中心T2DM患者的临床资料。采用逻辑回归分析计算阿朴脂蛋白水平对DN风险的比值比（OR）和95%置信区间（95%CI）。
本研究纳入的498例T2DM患者中，221例有微量白蛋白尿，105例有大量白蛋白尿，172例无任何肾病迹象。血清阿朴脂蛋白水平与舒张压、体重指数、甘油三酯、天冬氨酸转氨酶、丙氨酸转氨酶、肌酐、ACR和白蛋白与肌酐比值呈正相关（均P<0.05），与低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖、糖化血红蛋白和估计肾小球滤过率呈负相关（均P<0.05）。在调整协变量后，阿朴脂蛋白升高与糖尿病肾病相关（所有OR=2.560，95%CI：1.1592-4.116；P<0.001）。
血清阿朴脂蛋白水平显著增加DN风险，尤其是女性患者。
