金氏结节病问卷（KSQ）- 塞尔维亚语结节病患者人群的验证研究。
King's Sarcoidosis Questionnaire (KSQ) - Validation study in Serbian speaking population of sarcoidosis patients.
机构信息
Clinic of Pulmonology, University Clinical Center of Serbia, Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
PLoS One. 2023 Sep 5;18(9):e0273126. doi: 10.1371/journal.pone.0273126. eCollection 2023.
INTRODUCTION
Sarcoidosis is a multiorgan, multisystem chronic disease of unknown etiology and unpredictable course. Health status is reduced in sarcoidosis and assessing it is a difficult multitask effort due to many faces this disease might have. Recently, a new questionnaire for assessing health status in sarcoidosis was developed by a group of authors from England-King's Sarcoidosis Questionnaire (KSQ). The benefit of KSQ is the ability to develop the best care plan for the patient, as well as to differentiate the efficacy of the administered treatment.
OBJECTIVE
The aim of this study was to validate the KSQ in Serbian speaking population of sarcoidosis patients. The test itself is a modular, multi-organ health status measure for patients with sarcoidosis for use in clinic and the evaluation of therapies. The correlation of KSQ with different clinical course of sarcoidosis (acute vs chronic disease) and with the clinical outcome status (COS) in sarcoidosis was also investigated.
METHODS
A total of 159 biopsy positive sarcoidosis patients participated in this study. The average age of the participants was 49.67, majority was female (67.3%) and majority had only pulmonary form of sarcoidosis (71.7%). KSQ - new disease-specific health status instrument, was compared with 5 other already existing instruments already used and validated in sarcoidosis (Saint George Respiratory Questionnaire- SGRQ, Daily Activity List -DAL, Fatigue Assessment Scale- FAS, Medical Research Council dyspnea scale-MRC, Borg Dyspnea Scale and 15D as general questionnaire.
RESULTS
KSQ has significant correlation with other quality of life questionnaires already used in sarcoidosis. Translated version of KSQ shows significant internal reliability, similar to the original KSQ. Serbian version of KSQ has significant correlation with different clinical course of sarcoidosis and with COS as well. The translated version of KSQ is reliable sarcoidosis specific instrument for assessing health status in these patients.
简介
结节病是一种多器官、多系统的慢性疾病，病因不明，病程不可预测。结节病患者的健康状况下降，评估其健康状况是一项艰巨的多任务工作，因为这种疾病可能有多种表现。最近，一组来自英国的作者开发了一种新的用于评估结节病患者健康状况的问卷-King's Sarcoidosis Questionnaire（KSQ）。KSQ 的优点是能够为患者制定最佳的护理计划，并区分所给予治疗的效果。
目的
本研究的目的是验证 KSQ 在塞尔维亚语结节病患者中的有效性。KSQ 是一种模块化、多器官的健康状况衡量工具，用于评估结节病患者的健康状况和治疗效果。还研究了 KSQ 与结节病不同临床病程（急性与慢性疾病）以及与结节病临床结局状态（COS）的相关性。
方法
共有 159 名活检阳性的结节病患者参与了这项研究。参与者的平均年龄为 49.67 岁，大多数为女性（67.3%），大多数患者只有肺部结节病（71.7%）。KSQ-新的疾病特异性健康状况衡量工具，与其他 5 种已经在结节病中使用和验证的现有工具进行了比较（圣乔治呼吸问卷-SGRQ、日常活动表-DAL、疲劳评估量表-FAS、医学研究委员会呼吸困难量表-MRC、Borg 呼吸困难量表和一般问卷 15D）。
结果
KSQ 与已经在结节病中使用的其他生活质量问卷有显著相关性。翻译后的 KSQ 具有较高的内部信度，与原始 KSQ 相似。塞尔维亚语版的 KSQ 与结节病的不同临床病程以及与 COS 也有显著相关性。翻译后的 KSQ 是一种可靠的结节病特异性工具，可用于评估这些患者的健康状况。
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