Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.
BMC Pulm Med. 2021 Dec 3;21(1):395. doi: 10.1186/s12890-021-01761-7.
Sarcoidosis is granulomatous disease of unknown origin affecting organ function and quality of life. The King's Sarcoidosis Questionnaire (KSQ) serves as a tool to assess quality of life in sarcoidosis patients with general health and organ specific domains. A German translation has been validated in a German cohort. In this study we assessed, whether clinical parameters influence KSQ scores.
Clinical data (e.g. lung function, organ impairment, serological parameters) for the German validation cohort were extracted from clinical charts and investigated by correlation and linear regression analyses.
KSQ subdomain scores were generally lower in patients with respective organ manifestation or on current therapy. LUNG subdomain was significantly predicted by lung functional parameters, however for general health status, only FeV1 exerted significant influence. GHS was not influenced by serological parameters, but was significantly negatively correlated with body mass index (BMI). KSQ provides additional information beyond lung function, clinical or serological parameters in sarcoidosis patients. Notably, high BMI is significantly negatively associated with patients' well-being as measured by KSQ-GHS.
This observation may direct further studies investigating the effect of obesity on sarcoidosis-related quality of life and strategies to intervene with steroid-sparing therapies and measures of life style modifications. Trial registration This study was registered in the German Clinical Trials Register (reference number DRKS00010072). Registered January 2016.
结节病是一种病因不明的肉芽肿性疾病，会影响器官功能和生活质量。国王结节病问卷（KSQ）是一种用于评估结节病患者生活质量的工具，包括一般健康和器官特异性领域。该问卷的德文译本已经在德国队列中得到验证。在这项研究中，我们评估了临床参数是否会影响 KSQ 评分。
从临床图表中提取德国验证队列的临床数据（例如肺功能、器官损伤、血清学参数），并通过相关和线性回归分析进行研究。
具有相应器官表现或正在接受治疗的患者的 KSQ 子域评分通常较低。LUNG 子域与肺功能参数显著相关，但对于一般健康状况，只有 FeV1 具有显著影响。GHS 不受血清学参数影响，但与体重指数（BMI）显著负相关。KSQ 可提供结节病患者除肺功能、临床或血清学参数以外的额外信息。值得注意的是，较高的 BMI 与 KSQ-GHS 测量的患者幸福感显著负相关。
这一观察结果可能会促使进一步研究肥胖对结节病相关生活质量的影响，以及探索使用类固醇保留疗法和生活方式改变措施进行干预的策略。
本研究在德国临床试验注册处（注册号 DRKS00010072）进行注册。2016 年 1 月注册。
