Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Thorax. 2013 Jan;68(1):57-65. doi: 10.1136/thoraxjnl-2012-201962. Epub 2012 Oct 12.
Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.
Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.
207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's α coefficient was 0.70-0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=-0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r=-0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90-0.96.
The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients' perspective.
结节病患者的健康状况受损。目前评估结节病患者健康状况的工具很少。本研究的目的是开发和验证 King's Sarcoidosis Questionnaire（KSQ），这是一种新的模块化健康状况衡量工具。
从门诊诊所招募结节病患者。问卷的开发包括三个阶段：项目生成；项目减少，Rasch 分析创建单一维度量表和验证；重复性测试。
207 名结节病患者（器官受累：184 例肺部，54 例皮肤，45 例眼病）完成了一份 65 项初步问卷。由于冗余或与 Rasch 模型拟合不佳，有 36 个项目被删除。KSQ 的最终版本由五个模块组成（一般健康状况、肺部、皮肤、眼部、药物）。KSQ 模块的内部一致性用 Cronbach's α 系数评估为 0.70-0.93。肺部模块的同时效度与圣乔治呼吸问卷（r=-0.83）高度相关，与用力肺活量（r=0.49）中度相关。与皮肤特异性和眼部特异性测量的同时效度范围从 r=-0.4 到 0.8。KSQ 在 2 周内具有可重复性（n=39），模块的组内相关系数为 0.90-0.96。
KSQ 是一种简短、有效、自我完成的结节病健康状况衡量工具。它可以在诊所中用于从患者的角度评估结节病。
