1Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA.
2Department of Specialty Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ.
J Am Vet Med Assoc. 2023 Sep 4;261(12):1-9. doi: 10.2460/javma.23.06.0305. Print 2023 Dec 1.
To identify prognostic indicators and inflammatory markers associated with nonsurvival in dogs with gallbladder mucoceles (GBMs) following cholecystectomy and to evaluate C-reactive protein (CRP) and haptoglobin concentrations in dogs with GBMs compared to healthy controls.
25 dogs that underwent cholecystectomy for removal of GBM and 20 healthy control dogs.
A prospective, multicenter cohort study. Survival outcomes to hospital discharge and 2 weeks postdischarge were recorded from medical records. Laboratory variables, inflammatory markers (CRP and haptoglobin), and 25-hydroxyvitamin(OH) D (25[OH]D) concentrations were measured preoperatively. Associations between signalment, clinicopathologic variables, acute patient physiologic and laboratory evaluation (APPLEFAST) scores, inflammatory markers, 25(OH)D concentration, and survival were analyzed using logistic regression.
76% (19/25) and 68% (17/25) of dogs survived to hospital discharge and 2 weeks postdischarge, respectively. For each additional year of age, the odds of nonsurvival in hospital and 2 weeks postdischarge increased by 2.2 (P = .01; 95% CI, 1.2 to 5.0) and 1.7 (P = .04; 95% CI, 1.0 to 3.2), respectively. Intraoperative systolic blood pressure ≤ 65 mm Hg increased the probability of nonsurvival in hospital (P < .04). Gallbladder perforation, APPLEFAST scores, and preoperative serum concentrations of CRP, haptoglobin, and 25(OH)D were not associated with survival. Serum CRP and haptoglobin concentrations were greater in dogs with GBM compared to controls (P < .001).
Increasing age and intraoperative systolic blood pressure ≤ 65 mm Hg were associated with nonsurvival in dogs with GBM undergoing cholecystectomy. Serum CRP, haptoglobin, and 25(OH)D were not associated with nonsurvival postcholecystectomy in this sample population.
确定与接受胆囊切除术的胆囊黏液囊（GBM）狗的非生存相关的预后指标和炎症标志物，并评估与健康对照组相比，GBM 犬的 C 反应蛋白（CRP）和结合珠蛋白浓度。
25 只接受胆囊切除术切除 GBM 的狗和 20 只健康对照组狗。
前瞻性、多中心队列研究。从病历中记录住院和出院后 2 周的生存结果。术前测量实验室变量、炎症标志物（CRP 和结合珠蛋白）和 25-羟维生素 D（25[OH]D）浓度。使用逻辑回归分析犬种、临床病理变量、急性患者生理和实验室评估（APPLEFAST）评分、炎症标志物、25（OH）D 浓度与生存之间的关系。
分别有 76%（19/25）和 68%（17/25）的狗在住院和出院后 2 周时存活。每增加 1 岁，住院和出院后 2 周的非生存几率分别增加 2.2（P =.01；95%CI，1.2 至 5.0）和 1.7（P =.04；95%CI，1.0 至 3.2）。术中收缩压≤65mmHg 增加了住院期间非生存的可能性（P <.04）。胆囊穿孔、APPLEFAST 评分以及术前血清 CRP、结合珠蛋白和 25（OH）D 浓度与生存无关。与对照组相比，患有 GBM 的狗的血清 CRP 和结合珠蛋白浓度更高（P <.001）。
在接受胆囊切除术的 GBM 犬中，年龄增长和术中收缩压≤65mmHg 与非生存相关。在该样本人群中，术后血清 CRP、结合珠蛋白和 25（OH）D 与非生存无关。
