Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Korea.
Clin Mol Hepatol. 2023 Oct;29(4):844-850. doi: 10.3350/cmh.2023.0291. Epub 2023 Sep 6.
Steatotic liver disease was suggested as an overarching term encompassing various etiologies of hepatic steatosis. Experts from multinational liver societies went through the Delphi process, including four rounds of surveys, and consented to adopt a new nomenclature and definition instead of the conventional nonalcoholic fatty liver disease (NAFLD). This was to improve the understanding of the patients and primary care physicians, with an explanation of the pathophysiology in the name of the disease. Also, it could minimize the stigmatization of patients by using the histological neutral term "steatosis" instead of "fatty". Herein, we will discuss the changes and continuity between the two nomenclatures, metabolic dysfunction-associated steatotic liver disease (MASLD) and NAFLD, as well as the challenges to MASLD which need to be addressed in future.
脂肪性肝病被建议作为一个涵盖各种肝脂肪变性病因的总称。来自多国肝脏学会的专家们经历了德尔菲（Delphi）流程，包括四轮调查，并同意采用新的命名和定义，而不是传统的非酒精性脂肪性肝病（NAFLD）。这是为了提高患者和初级保健医生的理解，用疾病的名称来解释病理生理学。此外，通过使用组织学中性术语“脂肪变性”而不是“脂肪”，可以最小化患者的污名化。在此，我们将讨论两种命名法之间的变化和连续性，即代谢相关脂肪性肝病（MASLD）和 NAFLD，以及 MASLD 未来需要解决的挑战。
