Hou Ling, Su Ke, Zhao Jinbo, Li Yuanhong
Department of Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
Cardiovascular Disease Center, Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Enshi, Hubei Province, People's Republic of China.
Int J Gen Med. 2023 Aug 31;16:3977-3984. doi: 10.2147/IJGM.S427425. eCollection 2023.
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory disease that poses a significant health risk to individuals. Patients with COPD are predisposed to a higher incidence of coronary artery disease (CAD) than the general population. This study aims to investigate the correlation between COPD and the incidence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).
This study retrospectively analyzed the clinical data and laboratory test results of patients who underwent PCI at our hospital between January 2018 and December 2021 to investigate the relationship between COPD and drug-Eluting Stents (DES) postoperative ISR. We employed the best subset method to select the most suitable combination of predictive factors, utilizing the data, and verified the precision of the model by means of internal validation. We ultimately assessed the performance of the prediction model using an ROC curve.
The research indicates that COPD is an independent risk factor for ISR after PCI (OR=2.437, 95% CI [1.336, 4.495], P=0.004). The analysis revealed an area under the receiver operating characteristic (ROC) curve of 0.783 for the training group and 0.705 for the testing group, indicating a model fitting for both groups (both > 0.5).
COPD history is a dependable predictor of stent restenosis post percutaneous coronary intervention.
慢性阻塞性肺疾病（COPD）是一种常见的慢性呼吸道疾病，对个体健康构成重大风险。与普通人群相比，COPD患者更容易患冠状动脉疾病（CAD）。本研究旨在探讨COPD与经皮冠状动脉介入治疗（PCI）后支架内再狭窄（ISR）发生率之间的相关性。
本研究回顾性分析了2018年1月至2021年12月在我院接受PCI治疗的患者的临床资料和实验室检查结果，以研究COPD与药物洗脱支架（DES）术后ISR之间的关系。我们采用最佳子集法选择最合适的预测因素组合，并利用这些数据通过内部验证来验证模型的准确性。我们最终使用ROC曲线评估预测模型的性能。
研究表明，COPD是PCI术后ISR的独立危险因素（OR = 2.437，95% CI [1.336, 4.495]，P = 0.004）。分析显示，训练组的受试者操作特征（ROC）曲线下面积为0.783，测试组为0.705，表明两组模型拟合良好（均>0.5）。
COPD病史是经皮冠状动脉介入治疗后支架再狭窄的可靠预测指标。
