Tsai Chung-Yu, Liao Jia-Bin, Lee Yi-Chen, Yang Yi-Fang
Division of General Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
J Cancer. 2023 Aug 21;14(13):2552-2561. doi: 10.7150/jca.84460. eCollection 2023.
Genes of the homeobox (HOX) family encode transcription factors, which play a role in cancer progression. However, their role in gastric cancer has not been adequately evaluated. Herein, we evaluated the genetic changes and mRNA of target genes of the HOX family in gastric cancer patients using publicly available online datasets. We found that was amplified in gastric cancer tissues, and mRNA expression levels were significantly associated with tumor status (=0.044) and poor overall survival (<0.01). knockdown significantly reduced the viability of gastric cancer cell lines. modulated the expression of secreted phosphoprotein 1 (SPP1, osteopontin) and phosphorylation of AKT/ERK in gastric cancer cells. Survival analysis demonstrated a decrease in overall survival rates among the high /high expression group compared with the low /low expression group. In conclusion, may be an independent prognostic factor and serve as a useful predictive biomarker for gastric cancer.
同源盒（HOX）家族基因编码转录因子，其在癌症进展中发挥作用。然而，它们在胃癌中的作用尚未得到充分评估。在此，我们使用公开可用的在线数据集评估了胃癌患者中HOX家族靶基因的基因变化和mRNA情况。我们发现，[具体基因名称]在胃癌组织中扩增，且mRNA表达水平与肿瘤状态显著相关（P = 0.044），与总体生存率较差显著相关（P < 0.01）。[具体基因名称]敲低显著降低了胃癌细胞系的活力。[具体基因名称]调节了胃癌细胞中分泌性磷蛋白1（SPP1，骨桥蛋白）的表达以及AKT/ERK的磷酸化。生存分析表明，与低[具体基因名称]/低[具体基因名称]表达组相比，高[具体基因名称]/高[具体基因名称]表达组的总体生存率降低。总之，[具体基因名称]可能是一个独立的预后因素，并可作为胃癌有用的预测生物标志物。
