DNA自组装纳米花逆转慢性粒细胞白血病治疗中P-糖蛋白介导的耐药性。
DNA self-assembly nanoflower reverse P-glycoprotein mediated drug resistance in chronic myelogenous leukemia therapy.
作者信息
Zhao Pengxuan, Zhong Yeteng, Pan Pengcheng, Zhang Shasha, Tian Yu, Zhang Jun, Yi Guohui, Zhao Zhendong, Wu Tiantian
机构信息
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University, Haikou, China.
Department of Clinical Laboratory, The Second Affiliated Hospital, Hainan Medical University, Haikou, China.
出版信息
Front Bioeng Biotechnol. 2023 Aug 21;11:1265199. doi: 10.3389/fbioe.2023.1265199. eCollection 2023.
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder caused by the BCR-ABL chimeric tyrosine kinase. Vincristine (VCR) is widely used in leukemia therapy but is hindered by multidrug resistance (MDR). We prepared DNA nanoflower via self-assembly for the delivery of VCR and P-glycoprotein small interfering RNA (P-gp siRNA). The as-prepared nanoflower had a floriform shape with high loading efficiency of VCR (80%). Furthermore, the nanoflower could deliver VCR and P-gp siRNA into MDR CML cells and induce potent cytotoxicity both and , thus overcoming MDR of CML. Overall, this nanoflower is a promising tool for resistant CML therapy.
慢性粒细胞白血病（CML）是一种由BCR-ABL嵌合酪氨酸激酶引起的克隆性骨髓增殖性疾病。长春新碱（VCR）广泛应用于白血病治疗，但受到多药耐药性（MDR）的阻碍。我们通过自组装制备了DNA纳米花用于递送VCR和P-糖蛋白小干扰RNA（P-gp siRNA）。所制备的纳米花呈花状，VCR负载效率高（80%）。此外，纳米花可将VCR和P-gp siRNA递送至耐多药CML细胞，并在体内和体外诱导强效细胞毒性，从而克服CML的多药耐药性。总体而言，这种纳米花是治疗耐药CML的一种有前景的工具。
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