Department of Biochemistry and Molecular Biology, Johns Hopkins Bloom-berg School of Public Health, Baltimore, Maryland.
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Cancer Discov. 2023 Sep 6;13(9):1973-1981. doi: 10.1158/2159-8290.CD-23-0505.
Cancer is an age-related disease, with the majority of patients receiving their diagnosis after the age of 60 and most mortality from cancer occurring after this age. The tumor microenvironment changes drastically with age, which in turn affects cancer progression and treatment efficacy. Age-related changes to individual components of the microenvironment have received well-deserved attention over the past few decades, but the effects of aging at the interface of two or more microenvironmental components have been vastly understudied. In this perspective, we discuss the relationship between the aging extracellular matrix and the aging immune system, how they affect the tumor microenvironment, and how these multidisciplinary studies may open avenues for new therapeutics. Cancer is a disease of aging. With a rapidly aging population, we need to better understand the age-related changes that drive tumor progression, ranging from secreted changes to biophysical and immune changes.
癌症是一种与年龄相关的疾病，大多数患者在 60 岁以后被诊断出患有癌症，并且大多数癌症死亡发生在这个年龄之后。肿瘤微环境随着年龄的增长而发生巨大变化，这反过来又影响癌症的进展和治疗效果。过去几十年，人们对微环境中各个组成部分的与年龄相关的变化给予了充分的关注，但对两个或更多微环境组成部分界面的老化影响却研究甚少。在这篇观点文章中，我们讨论了衰老细胞外基质与衰老免疫系统之间的关系，以及它们如何影响肿瘤微环境，以及这些多学科研究如何为新的治疗方法开辟途径。癌症是一种衰老相关的疾病。随着人口老龄化的迅速发展，我们需要更好地了解驱动肿瘤进展的与年龄相关的变化，这些变化范围从分泌变化到生物物理和免疫变化。
