衰老相关的细胞外基质改变调节微环境并影响肿瘤进展。
Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression.
机构信息
Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA 98104, USA.
出版信息
Int J Cancer. 2010 Dec 15;127(12):2739-48. doi: 10.1002/ijc.25615. Epub 2010 Oct 8.
Abstract
Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.
摘要
年龄是上皮性癌症发生的最大风险因素。在这篇综述中，我们将研究关键的细胞外基质和基质细胞成分，以及它们随衰老的变化，并讨论这些变化如何影响老年宿主中癌症的后续进展。由于高龄与前列腺癌的高发率密切相关，因此在本篇综述中，我们将以前列腺癌作为模型。
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本文引用的文献
1
The effects of aging on the molecular and cellular composition of the prostate microenvironment.衰老对前列腺微环境的分子和细胞组成的影响。
PLoS One. 2010 Sep 1;5(9):e12501. doi: 10.1371/journal.pone.0012501.
2
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.衰老的成纤维细胞在早期卵巢癌的三维模型中促进部分转化的卵巢上皮细胞的肿瘤转化。
Neoplasia. 2010 Apr;12(4):317-25. doi: 10.1593/neo.91948.
3
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.血小板衍生的血栓反应蛋白-1 是血管生成的关键负调节剂和潜在的生物标志物。
Blood. 2010 Jun 3;115(22):4605-13. doi: 10.1182/blood-2009-09-242065. Epub 2010 Jan 19.
4
Collagen extracts derived from young and aged mice demonstrate different structural properties and cellular effects in three-dimensional gels.从年轻和老年小鼠中提取的胶原蛋白在三维凝胶中表现出不同的结构特性和细胞效应。
J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):209-18. doi: 10.1093/gerona/glp202. Epub 2010 Jan 15.
5
Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivity.前列腺癌细胞中 CD44 异构体表达的稳定改变可降低侵袭和生长能力，并改变配体结合和化疗敏感性。
BMC Cancer. 2010 Jan 14;10:16. doi: 10.1186/1471-2407-10-16.
6
Senescence in tumours: evidence from mice and humans.肿瘤衰老：来自小鼠和人类的证据。
Nat Rev Cancer. 2010 Jan;10(1):51-7. doi: 10.1038/nrc2772.
7
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Am J Transl Res. 2009 Jan 1;1(1):80-6.
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10
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