衰老相关的细胞外基质改变调节微环境并影响肿瘤进展。
Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression.
机构信息
Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA 98104, USA.
出版信息
Int J Cancer. 2010 Dec 15;127(12):2739-48. doi: 10.1002/ijc.25615. Epub 2010 Oct 8.
Abstract
Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.
摘要
年龄是上皮性癌症发生的最大风险因素。在这篇综述中，我们将研究关键的细胞外基质和基质细胞成分，以及它们随衰老的变化，并讨论这些变化如何影响老年宿主中癌症的后续进展。由于高龄与前列腺癌的高发率密切相关，因此在本篇综述中，我们将以前列腺癌作为模型。
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