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斑疹伤寒病例报告,伴有双侧急性感觉神经性听力损失和脑性盐耗综合征。

Case report of scrub typhus with bilateral acute sensorineural hearing loss and cerebral salt-wasting disease.

机构信息

Registrar, University Medical Unit, Colombo South Teaching Hospital, Kalubowila-Dehiwala, Sri Lanka.

Consultant Physician & Senior Lecturer, Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

出版信息

Trop Doct. 2024 Jan;54(1):69-71. doi: 10.1177/00494755231195933. Epub 2023 Sep 6.

Abstract

Scrub typhus is a re-emerging and endemic disease in the Asia Pacific region caused by . We present a 65-year-old male from Sri Lanka who presented with fever, bilateral acute sensorineural hearing loss, and confusion. On examination, he was dehydrated. Significant orthostatic hypotension and an eschar were noted. Investigations revealed hyponatraemia with elevated urine sodium, reduced serum osmolality, and normal urine osmolality suggestive of cerebral salt wasting. After initial hydration with 0.9% NaCl, hyponatraemia was corrected with 3% NaCl. Oral doxycycline was prescribed, and he showed dramatic clinical improvement. A diagnosis of typhus must be considered in a patient presenting with a febrile illness and acute hearing loss. Cerebral salt-wasting disease should be considered in a patient with typhus who develops hyponatraemia with dehydration. Furthermore, acute sensorineural hearing loss in both ears is an important manifestation of the disease.

摘要

恙虫病是亚太地区重新出现的地方性疾病,由恙虫病东方体引起。我们报告了一例来自斯里兰卡的 65 岁男性,他表现为发热、双侧急性感觉神经性听力损失和意识混乱。体格检查发现患者脱水,体位性低血压显著,有焦痂。检查发现低钠血症,尿钠升高,血清渗透压降低,尿渗透压正常,提示脑性盐耗综合征。最初用 0.9%氯化钠溶液补液,然后用 3%氯化钠溶液纠正低钠血症。给予口服多西环素治疗,患者的临床症状显著改善。发热伴急性听力损失的患者应考虑诊断为斑疹伤寒。恙虫病患者出现低钠血症伴脱水时应考虑脑性盐耗综合征。此外,双耳急性感觉神经性听力损失是该病的一个重要表现。

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