The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Ningbo No. 2 Hospital, Ningbo, China.
Arch Microbiol. 2023 Sep 6;205(10):326. doi: 10.1007/s00203-023-03665-y.
Hypervirulent Klebsiella pneumoniae (hvKp), characterized by high virulence and epidemic potential, has become a global public health challenge. Therefore, improving the identification of hvKp and enabling earlier and faster detection in the community to support subsequent effective treatment and prevention of hvKp are an urgent issue. To address these issues, a number of assays have emerged, such as String test, Galleria mellonella infection test, PCR, isothermal exponential amplification, and so on. In this paper, we have collected articles on the detection methods of hvKp and conducted a retrospective review based on two aspects: traditional detection technology and biomarker-based detection technology. We summarize the advantages and limitations of these detection methods and discuss the challenges as well as future directions, hoping to provide new insights and references for the rapid detection of hvKp in the future. The aim of this study is to focus on the research papers related to Hypervirulent Klebsiella pneumoniae involving the period from 2012 to 2022. We conducted searches using the keywords "Hypervirulent Klebsiella pneumoniae, biomarkers, detection techniques" on ScienceDirect and Google Scholar. Additionally, we also searched on PubMed, using MeSH terms associated with the keywords (such as Klebsiella pneumoniae, Klebsiella Infections, Virulence, Biomarkers, diagnosis, etc.).
高毒力肺炎克雷伯菌（hvKp）具有高致病性和强传染性，已成为全球公共卫生的挑战。因此，提高对 hvKp 的识别能力，实现社区内的早期、快速检测，以支持后续的有效治疗和预防 hvKp，是当务之急。为了解决这些问题，已经出现了一些检测方法，如 String 试验、大蜡螟感染试验、PCR、等温指数扩增等。在本文中，我们收集了关于 hvKp 检测方法的文献，并基于传统检测技术和基于生物标志物的检测技术两个方面进行了回顾性综述。我们总结了这些检测方法的优缺点，并讨论了面临的挑战及未来方向，希望为未来 hvKp 的快速检测提供新的思路和参考。本研究旨在聚焦于 2012 年至 2022 年期间与高毒力肺炎克雷伯菌相关的研究论文。我们在 ScienceDirect 和 Google Scholar 上使用关键词“Hypervirulent Klebsiella pneumoniae、biomarkers、detection techniques”进行了检索。此外，我们还在 PubMed 上使用了与关键词相关的 MeSH 术语（如 Klebsiella pneumoniae、Klebsiella Infections、Virulence、Biomarkers、diagnosis 等）进行了检索。
