基因治疗免疫球蛋白 E、补体介导和嗜酸性粒细胞疾病。
Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.
机构信息
Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA.
出版信息
Hum Gene Ther. 2023 Oct;34(19-20):986-1002. doi: 10.1089/hum.2023.039.
Abstract
Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders.
摘要
免疫球蛋白 E、补体和嗜酸性粒细胞在宿主防御中发挥着重要作用，但这些成分中的任何一种功能失调都可能导致各种人类疾病。在这篇综述中，我们总结了研究人员如何利用基因治疗和反义技术来调节免疫球蛋白 E、补体和/或嗜酸性粒细胞水平，以治疗这些疾病。
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