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基因治疗免疫球蛋白 E、补体介导和嗜酸性粒细胞疾病。

Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders.

机构信息

Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA.

出版信息

Hum Gene Ther. 2023 Oct;34(19-20):986-1002. doi: 10.1089/hum.2023.039.

DOI:10.1089/hum.2023.039
PMID:37672523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10616964/
Abstract

Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders.

摘要

免疫球蛋白 E、补体和嗜酸性粒细胞在宿主防御中发挥着重要作用，但这些成分中的任何一种功能失调都可能导致各种人类疾病。在这篇综述中，我们总结了研究人员如何利用基因治疗和反义技术来调节免疫球蛋白 E、补体和/或嗜酸性粒细胞水平，以治疗这些疾病。

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本文引用的文献

[1]
Eosinophils and eosinophilic immune dysfunction in health and disease.

Eur Respir Rev. 2022-3-31

[2]
Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis.

Allergy. 2022-6

[3]
Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.

N Engl J Med. 2021-12-9

[4]
Gene therapy in a murine model of chronic eosinophilic leukemia-not otherwise specified (CEL-NOS).

Leukemia. 2022-2

[5]
Eosinophils in Health and Disease: A State-of-the-Art Review.

Mayo Clin Proc. 2021-10

[6]
Treating severe asthma: Targeting the IL-5 pathway.

Clin Exp Allergy. 2021-8

[7]
Gene therapy for a murine model of eosinophilic esophagitis.

Allergy. 2021-9

[8]
Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation.

Eur Respir J. 2021-8

[9]
Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis.

J Allergy Clin Immunol. 2020-12

[10]
Rhinitis 2020: A practice parameter update.

J Allergy Clin Immunol. 2020-10

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