Bando K, Ichihara K, Shimotsuji T, Toyoshima H, Koda K, Hayashi C, Miyai K
Ann Clin Biochem. 1986 Mar;23 ( Pt 2):190-4. doi: 10.1177/000456328602300208.
Carnosinase hydrolyses carnosine in muscle, and its deficiency is associated with extensive neuromuscular abnormalities. We measured serum carnosinase activity in patients with thyroid dysfunction which often involves neuromuscular systems. In hyperthyroidism, the carnosinase activity was not significantly different from that in normal subjects. In hypothyroidism, however, it was significantly lower than that in normal subjects. The activity examined in five patients with hypothyroidism returned to normal after replacement therapy. In hypothyroidism, the carnosinase activity showed significant correlation with concentration of serum thyroxine and negative correlation with serum creatine kinase activity. This finding may be of practical importance in the differential diagnosis of disorders causing carnosinase deficiency.
肌肽酶可水解肌肉中的肌肽，其缺乏与广泛的神经肌肉异常有关。我们检测了常累及神经肌肉系统的甲状腺功能障碍患者的血清肌肽酶活性。在甲状腺功能亢进症患者中，肌肽酶活性与正常受试者无显著差异。然而，在甲状腺功能减退症患者中，其活性显著低于正常受试者。5例甲状腺功能减退症患者经替代治疗后，所检测的活性恢复正常。在甲状腺功能减退症中，肌肽酶活性与血清甲状腺素浓度呈显著正相关，与血清肌酸激酶活性呈负相关。这一发现可能对导致肌肽酶缺乏的疾病的鉴别诊断具有实际意义。
