Broughton P M, Holder R, Ashby D
Ann Clin Biochem. 1986 Jul;23 ( Pt 4):474-86. doi: 10.1177/000456328602300416.
A study has been made of the variations in monthly mean values of 10 serum constituents in subjects participating in two partly-concurrent long-term epidemiological surveys. Closely similar patterns of variation were found in men in both surveys and in men and women in one survey. During the 6 years of the study, four types of variation of the monthly mean concentrations were identified in varying combinations: abrupt changes of less than 2% not detected by quality control procedures; a gradual drift in mean value; haphazard variations in mean values; and seasonal variations in bilirubin and urea, identical in men and women. The implications of these findings for the design of long-term epidemiological surveys, and the criteria for designating variations as seasonal, are discussed.
对参与两项部分同期进行的长期流行病学调查的受试者血清中10种成分的月均值变化进行了研究。在两项调查中的男性以及其中一项调查中的男性和女性中均发现了极为相似的变化模式。在为期6年的研究中，确定了月平均浓度的四种变化类型，这些类型以不同组合出现：质量控制程序未检测到的小于2%的突然变化；均值的逐渐漂移；均值的随机变化；以及男性和女性中胆红素和尿素的季节性变化。讨论了这些发现对长期流行病学调查设计的影响以及将变化指定为季节性变化的标准。
