Harris E K, Brown S S
Ann Clin Biochem. 1979 Jul;16(4):169-76. doi: 10.1177/000456327901600142.
The distributions of within-person variances in the concentrations of 10 commonly assayed serum constituents have been derived from data on 37 healthy male subjects studied at weekly intervals over a period of five months. All 10 distributions appear to be of log-normal form. The relevance of the findings to the interpretation of differences between serial measurements in a given individual is discussed. Examples are given to show how the information on within-person variances for a particular analyte, organised into a simple graph, may be used to test medical opinions on threshold values for serial changes in the concentration of this analyte in a given individual. In this way, biological variability as well as analytical error may be taken into account quantitatively when assessing the significance of a difference between two serial measurements.
10种常用检测血清成分浓度的个体内方差分布，源自对37名健康男性受试者进行为期5个月、每周一次的研究数据。所有这10种分布似乎都呈对数正态形式。讨论了这些发现与解释给定个体连续测量值之间差异的相关性。给出了一些例子，展示了将特定分析物的个体内方差信息整理成简单图表后，如何用于检验关于该分析物在给定个体中浓度连续变化阈值的医学观点。通过这种方式，在评估两次连续测量之间差异的显著性时，可以定量地考虑生物变异性以及分析误差。
