Department of Nephrology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China.
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Chemosphere. 2023 Nov;341:140040. doi: 10.1016/j.chemosphere.2023.140040. Epub 2023 Sep 4.
Chronic kidney disease (CKD) is an inflammatory disease characterized by the deterioration of renal function, which imposes a significant burden on the healthcare system. In the recent decades, the ageing of the population and the increase of ozone pollution have accelerated. However, epidemiological associations between long-term ozone exposure and renal function in susceptible populations are understudied. In this study, we aimed to investigate the association of 1 y ozone exposure with renal function among the older adults in Xiamen City, China. We recruited 6024 eligible participants with a median age of 65.00 years, estimated their ozone exposure data, and collected questionnaires on demographic status and lifestyle factors as well as information on healthcare access. A generalized linear model was used to assess the association. An increase of 10 μg/m of 1 y ozone exposure was negatively associated with the estimated glomerular filtration rate (eGFR) [-3.12 (95% CI: -4.76, -1.48)]. The associations were stronger in men, non-smokers, and those with hypertension or T2DM. Clinical indicators of high-density lipoprotein, low-density lipoprotein, triglycerides, and total cholesterol were the main mediators to regulate the ozone-renal function association. Our results suggested that long-term ozone exposure is a potential risk factor for renal function in Chinese middle-aged and elderly adults.
慢性肾脏病（CKD）是一种以肾功能恶化为特征的炎症性疾病，给医疗保健系统带来了巨大负担。近几十年来，人口老龄化和臭氧污染加剧。然而，长期臭氧暴露与易感人群肾功能之间的流行病学关联研究较少。在这项研究中，我们旨在调查中国厦门市老年人群中 1 年臭氧暴露与肾功能之间的关系。我们招募了 6024 名符合条件的参与者，中位年龄为 65.00 岁，估计了他们的臭氧暴露数据，并收集了有关人口统计学状况和生活方式因素以及医疗保健获取信息的问卷。使用广义线性模型评估关联。1 年的臭氧暴露增加 10μg/m，与估算肾小球滤过率（eGFR）呈负相关[-3.12（95%CI：-4.76，-1.48)]。在男性、不吸烟者以及患有高血压或 T2DM 的人群中，相关性更强。高密度脂蛋白、低密度脂蛋白、甘油三酯和总胆固醇的临床指标是调节臭氧-肾功能关联的主要中介物。我们的研究结果表明，长期臭氧暴露是中国中老年人肾功能的一个潜在危险因素。
