Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Tongji University, Shanghai 200120, China; Institute of Clinical Epidemiology and Evidence - Based Medicine, Tongji University School of Medicine, Shanghai 200092, PR China.
Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai 200000, China.
Public Health. 2020 Apr;181:196-201. doi: 10.1016/j.puhe.2020.01.001. Epub 2020 Feb 28.
We investigated whether long-term ambient air pollutants (AAP) exposure was associated with estimated glomerular filtration rate (eGFR) among hospitalized patients living in urban areas of Shanghai, China.
This was a cross-sectional observational study.
A total of 3622 newly hospitalized inpatients were investigated from October 2014 to May 2015. The prior year's average exposure to particulate matter (PM) of each participant was estimated using the Kriging interpolation method of ArcGIS. The estimated eGFR was calculated according to the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Both generalized linear and logistic regression models were applied to assess the associations between AAP and renal function.
One-year PM exposure was associated with lower eGFR; each standard deviation (SD) increase in PM was significantly associated with the increased prevalence of CKD [adjusted odds ratio (OR) 1.11; 95% confidence interval (CI): 1.02, 1.21], and lower eGFR by -0.40 (95%CI: -0.80, -0.01) ml/min/1.73 m. Moreover, the effect of PM was significantly greater in people over 65 years old.
Our results supported that exposure to ambient PM increased the risk of CKD and negatively affected renal function among Chinese adults.
我们研究了长期暴露于环境空气污染物（AAP）是否与中国上海城区住院患者的估算肾小球滤过率（eGFR）有关。
这是一项横断面观察性研究。
本研究共纳入了 2014 年 10 月至 2015 年 5 月期间的 3622 名新住院患者。采用 ArcGIS 的克里金插值法估算每位参与者前一年的平均 PM 暴露量。根据慢性肾脏病流行病学合作（CKD-EPI）方程计算估算的 eGFR。采用广义线性和逻辑回归模型评估 AAP 与肾功能之间的关联。
一年的 PM 暴露与 eGFR 降低有关；PM 每增加一个标准差（SD），与 CKD 的患病率增加显著相关[调整后的优势比（OR）为 1.11；95%置信区间（CI）：1.02，1.21]，eGFR 降低-0.40（95%CI：-0.80，-0.01）ml/min/1.73m。此外，PM 的影响在 65 岁以上人群中更为显著。
我们的研究结果表明，暴露于环境 PM 会增加中国成年人患 CKD 的风险，并对其肾功能产生负面影响。
