Goh Josh T, Balmain Bryce N, Wilhite Daniel P, Granados Jorge, Sandy Lydia L, Liu Yu-Lun, Pawelczyk James A, Babb Tony G
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Respir Physiol Neurobiol. 2023 Dec;318:104151. doi: 10.1016/j.resp.2023.104151. Epub 2023 Sep 6.
We investigated whether older adults (OA) with obesity are more likely to have dyspnea compared with OA without obesity, and whether OA with obesity are at a greater risk of having dyspnea compared with middle-aged (MA) and younger adults (YA) with obesity. We obtained de-identified data from the TriNetX UT Southwestern Medical Center database. We identified obesity and dyspnea using ICD-10-CM codes E66 and R06.0, respectively. Patients were separated into three age groups: OA, (65-75 y.o.), MA (45-55 y.o.), and YA (25-35 y.o). Within these groups, those with and without obesity or dyspnea were identified for analysis. The risk of dyspnea was greater in OA (risk ratio: 3.64), MA (risk ratio: 3.52), and YA (risk ratio: 2.76) with obesity compared with age-matched patients without obesity (all p < 0.01). The risk of dyspnea was greater in OA and MA with obesity compared with YA with obesity (both p < 0.001 vs. YA). These findings suggest that clinicians should consider obesity as an independent risk factor for dyspnea.
我们调查了肥胖的老年人（OA）与非肥胖的老年人相比是否更易出现呼吸困难，以及肥胖的老年人与肥胖的中年人（MA）和年轻人（YA）相比出现呼吸困难的风险是否更高。我们从TriNetX德克萨斯大学西南医学中心数据库获取了去识别化数据。我们分别使用ICD-10-CM编码E66和R06.0来识别肥胖和呼吸困难。患者被分为三个年龄组：老年人（65 - 75岁）、中年人（45 - 55岁）和年轻人（25 - 35岁）。在这些组中，识别出有或没有肥胖或呼吸困难的患者进行分析。与年龄匹配的非肥胖患者相比，肥胖的老年人（风险比：3.64）、中年人（风险比：3.52）和年轻人（风险比：2.76）出现呼吸困难的风险更高（所有p < 0.01）。与肥胖的年轻人相比，肥胖的老年人和中年人出现呼吸困难的风险更高（与年轻人相比，两者p < 0.001）。这些发现表明临床医生应将肥胖视为呼吸困难的一个独立风险因素。
