感知心脏毒性中的线粒体DNA应激。
Sensing mitochondrial DNA stress in cardiotoxicity.
作者信息
Ding Yang-Nan, Tang Xiaoqiang
机构信息
Department of Laboratory Medicine, Third Affiliated Hospital of Zhengzhou University, 7 Kangfu Qian Street, Zhengzhou, Henan 450052, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; National Health Commission Key Laboratory of Chronobiology, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; Development and Related Diseases of Women and Children, Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, No. 17 People's South Road, Chengdu, Sichuan 610041, China.
出版信息
Trends Endocrinol Metab. 2023 Nov;34(11):688-690. doi: 10.1016/j.tem.2023.08.012. Epub 2023 Sep 4.
Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.
细胞质中的线粒体DNA（mtDNA）可触发干扰素反应以促进疾病进展，但mtDNA的传感机制仍不清楚。雷等人发现，Z-DNA结合蛋白1（ZBP1）与环磷酸鸟苷-腺苷合成酶（cGAS）协同作用，以感知Z型mtDNA并传递mtDNA应激信号，从而促进诸如心脏毒性等疾病的发生，这为mtDNA应激情况提供了重要信息。
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