Obata Shumpei, Matsumoto Riko, Iwasa Maki, Kakinoki Masashi, Sawada Osamu, Sawada Tomoko, Saishin Yoshitsugu, Ohji Masahito
Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan.
Graefes Arch Clin Exp Ophthalmol. 2023 Nov;261(11):3207-3213. doi: 10.1007/s00417-023-06227-6. Epub 2023 Sep 6.
To evaluate the visual field after anti-vascular endothelial growth factor (VEGF) therapy and laser treatment for retinopathy of prematurity.
Retrospective cohort study. Infants with retinopathy of prematurity treated by anti-VEGF therapy or laser treatment were included in the study. Degrees of visual field in eight directions examined by Goldmann perimeter (intensity, 1000 apostilb; size, V4e = 64 mm) were compared between the anti-VEGF therapy and laser treatment groups. The visual acuity (VA) and spherical equivalent refraction were also compared between the two groups.
Nine eyes with anti-VEGF therapy and 12 eyes with laser treatment were enrolled in the analysis. The total, upper, nasal upper, nasal, nasal lower, temporal lower, and temporal upper visual fields were significantly wider in the eyes with anti-VEGF therapy than in those with laser treatment (496 vs 416, P = .002; 53 vs 45, P = .008; 56 vs 43, P = .003; 58 vs 39, P < .001; 55 vs 44, P = .01; 72 vs 65, P = .01; and 62 vs 56, P = .03, respectively). The logarithm of the minimum angle of resolution VA tended to be better in the eyes with anti-VEGF therapy than in those with laser treatment (0.01 vs 0.15, P = .06). Eyes with anti-VEGF therapy had significantly lower myopia than those with laser treatment (spherical equivalent refraction: -0.72 vs -5.7, P = .001).
Anti-VEGF therapy may provide a wider visual field, better VA, and less myopia compared with laser treatment.
评估抗血管内皮生长因子（VEGF）治疗和激光治疗早产儿视网膜病变后的视野情况。
回顾性队列研究。纳入接受抗VEGF治疗或激光治疗的早产儿视网膜病变婴儿。比较抗VEGF治疗组和激光治疗组通过Goldmann视野计（亮度，1000 apostilb；大小，V4e = 64 mm）在八个方向检查的视野度数。还比较了两组的视力（VA）和等效球镜度。
分析纳入了9只接受抗VEGF治疗的眼睛和12只接受激光治疗的眼睛。接受抗VEGF治疗的眼睛的总视野、上视野、鼻上视野、鼻侧视野、鼻下视野、颞下视野和颞上视野明显比接受激光治疗的眼睛更宽（分别为496对416，P = 0.002；53对45，P = 0.008；56对43，P = 0.003；58对39，P < 0.001；55对44，P = 0.01；72对65，P = 0.01；62对56，P = 0.03）。接受抗VEGF治疗的眼睛的最小分辨角对数视力倾向于比接受激光治疗的眼睛更好（0.01对0.15，P = 0.06）。接受抗VEGF治疗的眼睛的近视程度明显低于接受激光治疗的眼睛（等效球镜度：-0.72对-5.7，P = 0.001）。
与激光治疗相比，抗VEGF治疗可能提供更宽的视野、更好的视力和更低的近视发生率。
