Anwar M, Mondestin H, Mojica N, Novo R, Graff M, Hiatt M, Hegyi T
Arch Dis Child. 1986 Sep;61(9):891-5. doi: 10.1136/adc.61.9.891.
We studied the efficacy of caffeine in improving pneumogram abnormalities and relieving clinically important apnoea of infancy in 23 infants. After obtaining a 12 hour pneumogram we administered caffeine citrate in a loading dose of 20 mg/kg followed by 5 mg/kg once daily. This dose achieved a trough caffeine blood concentration of 9.6 (SD 2.0) micrograms/ml. A repeat pneumogram performed seven to 10 days after the first pneumogram showed a significant reduction in the number of short and prolonged attacks of apnoea as well as in the per cent periodic breathing and apnoea density. Episodes of prolonged apnoea disappeared in all infants after administration of caffeine and in 11 infants all pneumogram abnormalities resolved. This improvement in the results of pneumograms was associated with resolution of clinically important apnoea requiring intervention. Caffeine was administered for 3.4 (SD 1.3) months and was well tolerated by all except two infants. We conclude that treatment with caffeine is helpful in preventing attacks of apnoea that require intervention, and improvement in the results of pneumograms after administration of caffeine predicts this favourable response.
我们研究了咖啡因对23名婴儿改善呼吸描记图异常及缓解具有临床意义的婴儿期呼吸暂停的疗效。在获取12小时呼吸描记图后，我们给予枸橼酸咖啡因负荷剂量20mg/kg，随后每日一次5mg/kg。该剂量使咖啡因血药谷浓度达到9.6（标准差2.0）μg/ml。在首次呼吸描记图后7至10天进行的重复呼吸描记图显示，呼吸暂停的短暂发作和延长发作次数以及周期性呼吸百分比和呼吸暂停密度均显著降低。给予咖啡因后，所有婴儿的延长呼吸暂停发作均消失，11名婴儿的所有呼吸描记图异常均得到解决。呼吸描记图结果的这种改善与需要干预的具有临床意义的呼吸暂停的解决相关。咖啡因给药3.4（标准差1.3）个月，除两名婴儿外，所有婴儿耐受性良好。我们得出结论，咖啡因治疗有助于预防需要干预的呼吸暂停发作，且给予咖啡因后呼吸描记图结果的改善预示着这种良好反应。
