Department of Obstetrics and Gynecology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Department of Infectious Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
J Obstet Gynaecol Res. 2023 Dec;49(12):2929-2937. doi: 10.1111/jog.15782. Epub 2023 Sep 6.
This study aimed to determine whether the weight-adjusted-waist index (WWI) affected infertility in women of childbearing age in the United States.
In this study, a database from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES) was used. We analyzed 3374 participants' data cross-sectionally. The survey used WWI and fertility status as independent and dependent variables. To determine the effect of WWI, an analysis of the independent relationship between WWI and infertility was conducted using weighted multivariable logistic regression and a generalized additive mode (GAM). A smooth curve fitting test was used to calculate whether there was a linear association between WWI and the incidence rate of infertility, as well as subgroup analyses and interaction tests.
The prevalence of infertility was 10.19% among 3374 participants. Higher WWI quartiles were associated with higher infertility rates. Based on a fully adjusted model, the effects of WWI on fertility were positive (odds ratio = 1.39, 95% confidence interval: 1.17-1.66). As a result of smooth curve fitting, the association was linear across the entire WWI. Different characteristics were associated with different risks of infertility in subgroup analysis.
Among women of reproductive age in the United States, WWI levels were positively associated with infertility. This relationship needs to be confirmed by further studies.
本研究旨在确定体重调整腰围指数（WWI）是否会影响美国育龄妇女的生育能力。
本研究使用了 2013 年至 2018 年全国健康和营养检查调查（NHANES）的数据库。我们对 3374 名参与者的数据进行了横断面分析。该调查将 WWI 和生育状况作为独立和因变量。为了确定 WWI 的影响，使用加权多变量逻辑回归和广义加性模型（GAM）对 WWI 与不孕之间的独立关系进行了分析。使用平滑曲线拟合检验来计算 WWI 与不孕发生率之间是否存在线性关联，以及进行亚组分析和交互检验。
在 3374 名参与者中，不孕的患病率为 10.19%。较高的 WWI 四分位数与较高的不孕率相关。基于完全调整模型，WWI 对生育能力的影响为正（优势比=1.39，95%置信区间：1.17-1.66）。通过平滑曲线拟合，整个 WWI 范围内的关联呈线性。在亚组分析中，不同的特征与不同的不孕风险相关。
在美国育龄妇女中，WWI 水平与不孕呈正相关。这一关系需要进一步的研究来证实。
