Zhang Hong, Yu Minmin, Li Li, Chen Chen, He Qinyuan
Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Obstetrics and Gynecology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
J Int Med Res. 2025 Feb;53(2):3000605251315019. doi: 10.1177/03000605251315019.
Obesity can contribute to infertility, but the exact relationship between infertility risk and obesity-related measurements like waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CoI), and A body shape index (ABSI) in women is uncertain. We investigated the association between these indices and female infertility.
In this cross-sectional study, we used National Health and Nutrition Examination Survey data (2013-2018). We used weighted multivariable logistic regression analysis, receiver operating characteristic (ROC) curves, and subgroup analysis, as well as propensity score matching.
Among 3373 participants, 344 (10.2%) reported infertility. A significant link between higher infertility risk and increased WHtR, BRI, CoI, ABSI, and body mass index (BMI) was found. Multivariable logistic regression analysis showed WHtR (odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.14-1.42), BRI (OR = 1.09, 95% CI: 1.05-1.14), CoI (OR = 1.36, 95% CI: 1.18-1.56), ABSI (OR = 1.22, 95% CI: 1.12-1.33), and BMI (OR = 1.03, 95% CI: 1.02-1.05) were significantly associated with female infertility. CoI had the best diagnostic performance (area under the ROC curve 0.628, 95% CI: 0.597-0.658).
Obesity-related indices were positively linked to infertility risk among women in the United States. These indices serve as valuable tools for assessing female infertility risk.
肥胖会导致不孕，但女性不孕风险与肥胖相关指标如腰高比（WHtR）、身体圆润度指数（BRI）、锥度指数（CoI）和A体型指数（ABSI）之间的确切关系尚不确定。我们研究了这些指标与女性不孕之间的关联。
在这项横断面研究中，我们使用了国家健康与营养检查调查数据（2013 - 2018年）。我们采用加权多变量逻辑回归分析、受试者工作特征（ROC）曲线、亚组分析以及倾向得分匹配。
在3373名参与者中，344人（10.2%）报告有不孕情况。研究发现，较高的不孕风险与WHtR、BRI、CoI、ABSI以及体重指数（BMI）升高之间存在显著关联。多变量逻辑回归分析显示，WHtR（比值比[OR] = 1.27，95%置信区间[CI]：1.14 - 1.42）、BRI（OR = 1.09，95% CI：1.05 - 1.14）、CoI（OR = 1.36，95% CI：1.18 - 1.56）、ABSI（OR = 1.22，95% CI：1.12 - 1.33）和BMI（OR = 1.03，95% CI：1.02 - 1.05）与女性不孕显著相关。CoI具有最佳的诊断性能（ROC曲线下面积为0.628，95% CI：0.597 - 0.658）。
在美国女性中，肥胖相关指标与不孕风险呈正相关。这些指标是评估女性不孕风险的有价值工具。
