睡眠限制对肥胖和糖尿病患者瘦素水平的影响。
The Role of Sleep Curtailment on Leptin Levels in Obesity and Diabetes Mellitus.
机构信息
School of Nursing and Midwifery, Edith Cowan University, Joondalup, Washington, Australia,
Mazandaran University of Medical Sciences, Emam Khomeini Hospital, Mazandaran, Iran.
出版信息
Obes Facts. 2021;14(2):214-221. doi: 10.1159/000514095. Epub 2021 Mar 23.
Abstract
Emerging evidence has identified sleep as a significant, but modifiable, risk factor for metabolic syndrome, diabetes, and obesity. Leptin, an adipocyte-derived peptide and a regulator of food intake and energy expenditure, has been shown to be associated with a short sleep duration in the pathophysiology of obesity and consequently type 2 diabetes. This review focuses on the current evidence indicating the effects of a short sleep duration on the regulation of leptin concentration in association with obesity and diabetes mellitus. In summary, the evidence suggests that sleep deprivation, by affecting leptin regulation, may lead to obesity and consequently development of type 2 diabetes through increased appetite and food intake. However, findings on the role of leptin in diabetes due to sleep deprivation are contradictory, and further studies with larger sample sizes are needed to confirm previous findings.
摘要
新出现的证据表明，睡眠是代谢综合征、糖尿病和肥胖的一个重要但可改变的危险因素。瘦素是一种脂肪细胞衍生的肽，是调节食物摄入和能量消耗的物质，它与肥胖患者的生理病理中睡眠持续时间过短有关，而肥胖则会导致 2 型糖尿病。这篇综述重点介绍了目前的证据，这些证据表明，短时间的睡眠会影响瘦素的调节，从而导致肥胖，进而发展为 2 型糖尿病，其作用机制可能是通过增加食欲和食物摄入。然而，由于睡眠剥夺导致的瘦素在糖尿病中的作用的研究结果存在矛盾，需要进一步开展更大规模的研究来证实之前的发现。
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