Koziol James A, Schnitzer Jan E
Proteogenomics Research Institute for Systems Medicine La Jolla, California USA.
Med Res Arch. 2023 Aug;11(8). doi: 10.18103/mra.v11i8.4248. Epub 2023 Aug 29.
Obesity and old age are commonly assumed to be risk factors for COVID-19 mortality. On a worldwide basis, we examine quantitative measures of obesity and elderly in the populations of individual countries and territories, and investigate whether these measures are predictive of COVID-19 mortality in those countries. In particular, we highlight regional differences relative to obesity and elderly metrics, and how these relate to COVID-19 mortality.
In this retrospective, population-based study, we obtained data relating to percentages of obese or elderly individuals in 199 countries, as well as COVID-19 mortality rates in these countries. We used negative binomial regression analyses to assess associations between COVID-19 mortality rates and the putative risk factors, in six regions - Africa, Asia, Europe, North America, Oceania, and South America.
We found significant differences between regions relative to COVID-19 mortality, as well as obesity and elderly population proportions. There were also substantial differences between countries within regions relative to proportions of obesity and elderly individuals, and COVID-19 mortality.
There are significant differences both between regions and within regions relative to COVID-19 mortality rates, as well as proportions of obese or elderly individuals. A global pronouncement that obesity and elderly constitute definitive risk factors for COVID-19 mortality masks the subtleties engendered by these intra- and inter-regional differences.
肥胖和老年通常被认为是新冠病毒病（COVID-19）死亡的风险因素。在全球范围内，我们研究了各个国家和地区人口中肥胖和老年情况的量化指标，并调查这些指标是否能预测这些国家的COVID-19死亡率。特别是，我们强调了肥胖和老年指标的区域差异，以及这些差异与COVID-19死亡率的关系。
在这项基于人群的回顾性研究中，我们获取了199个国家肥胖或老年个体百分比的数据，以及这些国家的COVID-19死亡率。我们使用负二项回归分析来评估六个地区（非洲、亚洲、欧洲、北美洲、大洋洲和南美洲）的COVID-19死亡率与假定风险因素之间的关联。
我们发现不同地区在COVID-19死亡率、肥胖和老年人口比例方面存在显著差异。各地区内不同国家在肥胖和老年个体比例以及COVID-19死亡率方面也存在很大差异。
在COVID-19死亡率以及肥胖或老年个体比例方面，地区之间和地区内部都存在显著差异。关于肥胖和老年是COVID-19死亡的决定性风险因素的全球论断掩盖了这些区域内和区域间差异所产生的微妙之处。
