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边缘区细胞淋巴瘤患者的持续性凋亡性肠病

Persistent Apoptotic Enteropathy in an Individual With Marginal Cell Lymphoma.

作者信息

Yuquimpo Kyle, Nathani Piyush, Patel Harsh, Decino Andrea, Unegbu Fortune, Hamza Ameer

机构信息

Division of Gastroenterology, Hepatology, & Motility, University of Kansas Medical Center, Kansas City, KS.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS.

出版信息

ACG Case Rep J. 2023 Sep 5;10(9):e01112. doi: 10.14309/crj.0000000000001112. eCollection 2023 Sep.

DOI:10.14309/crj.0000000000001112
PMID:37674883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10479344/
Abstract

Apoptotic enteropathy is a histological finding of increased crypt apoptosis that is commonly associated with diarrhea. Several etiologies for this disease state including immunodeficiency, autoimmune, infection, hereditary, checkpoint inhibitors, immunosuppressants, and immunomodulators have been previously described. We describe an extremely rare case of a patient with marginal cell lymphoma treated with bendamustine, rituximab, and obinutuzumab presenting with severe, relapsing, chronic diarrhea with persistent apoptotic enteropathy of unknown etiology, despite hematological remission and discontinuation of treatment for 1 year.

摘要

凋亡性肠病是一种隐窝凋亡增加的组织学表现，通常与腹泻有关。此前已描述过该疾病状态的多种病因，包括免疫缺陷、自身免疫、感染、遗传、检查点抑制剂、免疫抑制剂和免疫调节剂。我们描述了一例极为罕见的病例，一名边缘区细胞淋巴瘤患者接受了苯达莫司汀、利妥昔单抗和奥妥珠单抗治疗，尽管血液学缓解且停药1年，但仍出现严重的、复发性慢性腹泻，并伴有病因不明的持续性凋亡性肠病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cee/10479344/678910c7ae22/ac9-10-e01112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cee/10479344/769e47cb8c5e/ac9-10-e01112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cee/10479344/678910c7ae22/ac9-10-e01112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cee/10479344/769e47cb8c5e/ac9-10-e01112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cee/10479344/678910c7ae22/ac9-10-e01112-g002.jpg

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本文引用的文献

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三级中心 21 例患者与利妥昔单抗相关的原发性结肠炎。
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