Izzo Paolo, Izzo Luciano, Lai Silvia, D'Onghia Giuliano, Giancontieri Paola, Gabriele Raimondo, Polistena Andrea, Sibio Simone, Costanzo Maria Ludovica, De Intinis Claudia, Izzo Sara
"Pietro Valdoni" Department of Surgery, Policlinico "Umberto I", "Sapienza" University of Rome, Rome, Italy.
Department of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Rome, Italy.
Front Oncol. 2023 Aug 22;13:1216725. doi: 10.3389/fonc.2023.1216725. eCollection 2023.
Cutaneous metastases from urothelial carcinoma (UC) are very rare and indicate advanced disease with a poor prognosis. A 63-year-old female patient with a history of urothelial bladder carcinoma, treated 2 months prior with radical cystectomy and adjuvant gemcitabine and cisplatin (GC) therapy, presented a skin lesion localized in the lower third of the right leg. Punch biopsy revealed carcinomatous metastasis whose urothelial origin was confirmed by immunohistochemical analysis. 18-FDG PET-CT showed the spread of metastases to the lung and left ischium. Our review focuses on the time between surgery and skin metastasis, localization, and prognosis after metastasis diagnosis. In many cases, skin metastases occur within one year of initial UC surgery and in most cases occur on the abdominal wall. Local wide excision of metastasis should be considered in selected cases; however, chemotherapy remains the main treatment.
尿路上皮癌（UC）的皮肤转移非常罕见，提示疾病进展且预后不良。一名63岁女性患者，有膀胱尿路上皮癌病史，2个月前接受了根治性膀胱切除术及吉西他滨和顺铂（GC）辅助治疗，现右下肢下1/3处出现一处皮肤病变。穿刺活检显示为癌转移，免疫组化分析证实其起源于尿路上皮。18-FDG PET-CT显示转移灶扩散至肺部和左侧坐骨。我们的综述聚焦于手术与皮肤转移之间的时间、转移灶的定位以及转移诊断后的预后。在许多病例中，皮肤转移发生在初次UC手术后一年内，且大多数发生在腹壁。对于部分病例，应考虑对转移灶进行局部广泛切除；然而，化疗仍是主要的治疗方法。
