Wagner F, Wahl M
Arch Int Pharmacodyn Ther. 1986 Aug;282(2):240-51.
The effect of neurotensin (NT) was investigated in several vascular and intestinal smooth muscle preparations. No effect of NT (6 X 10(-12)-6 X 10(-5) M) was detected in feline pial arteries in situ employing perivascular microapplication and TV-image splitting for the measurement of vascular diameter. In vitro, the effect of NT was derived from recordings of isometric contraction. NT (10(-10)-10(-5) M) did not influence basal tension, frequency and peak phasic contraction of the whole guinea-pig portal vein (GPV) or its longitudinal strip (GLSPV). Intact reactivity of these preparations was derived from the contraction induced by carbamoylcholine or norepinephrine. In contrast, NT (6 X 10(-10)-6 X 10(-6) M) increased basal tension, frequency, and peak phasic contraction of the longitudinal strip of rat portal vein (RLSPV). Furthermore, NT induced a dose-dependent contraction in the terminal ileum of the guinea-pig (GTI) which was preceded by a transient relaxation. Comparing the effects obtained in GPV and GTI or found in RLSPV and GLSPV it is evident that the variable effects of NT depend on the location of smooth muscle and on animal species, respectively.
研究了神经降压素（NT）在几种血管和肠道平滑肌制剂中的作用。采用血管周围微量给药和电视图像分割法测量血管直径，未在原位猫软脑膜动脉中检测到NT（6×10⁻¹² - 6×10⁻⁵ M）的作用。在体外，NT的作用源自等长收缩记录。NT（10⁻¹⁰ - 10⁻⁵ M）不影响整个豚鼠门静脉（GPV）或其纵向条带（GLSPV）的基础张力、频率和相位收缩峰值。这些制剂的完整反应性源自卡巴胆碱或去甲肾上腺素诱导的收缩。相比之下，NT（6×10⁻¹⁰ - 6×10⁻⁶ M）增加了大鼠门静脉纵向条带（RLSPV）的基础张力、频率和相位收缩峰值。此外，NT在豚鼠回肠末端（GTI）诱导了剂量依赖性收缩，收缩前有短暂的舒张。比较在GPV和GTI中获得的效应或在RLSPV和GLSPV中发现的效应，很明显NT的不同效应分别取决于平滑肌的位置和动物物种。
