Adler A G, Leahy J J, Cressman M D
Arch Intern Med. 1986 Oct;146(10):1927-30.
Sublingual nifedipine was administered perioperatively to 19 elderly (age, greater than or equal to 60 years) patients undergoing ophthalmologic surgery. All of the patients had blood pressures exceeding 200 mm Hg systolic or 110 mm Hg diastolic, and 18 of the patients had both. Average (mean +/- SD) systolic blood pressure fell from 224.9 +/- 13.9 mm Hg to 154.6 +/- 19.0 mm Hg, while average diastolic blood pressure was reduced from 121.5 +/- 12.2 mm Hg to 78.1 +/- 10.6 mm Hg. Mean time to onset of response to nifedipine was 9.47 +/- 3.9 minutes, while the maximum antihypertensive response occurred in 35.3 +/- 10.2 minutes. A prompt antihypertensive response was obtained without any serious side effects. To our knowledge, this is the first reported study demonstrating the efficacy and safety of using sublingual nifedipine for the management of perioperative hypertension.
在围手术期，对19名接受眼科手术的老年患者（年龄大于或等于60岁）给予舌下含服硝苯地平。所有患者的收缩压均超过200 mmHg或舒张压超过110 mmHg，其中18名患者两者均超标。平均（均值±标准差）收缩压从224.9±13.9 mmHg降至154.6±19.0 mmHg，而平均舒张压从121.5±12.2 mmHg降至78.1±10.6 mmHg。硝苯地平起效的平均时间为9.47±3.9分钟，最大降压反应出现在35.3±10.2分钟。获得了迅速的降压反应且无任何严重副作用。据我们所知，这是首次报道的证明舌下含服硝苯地平治疗围手术期高血压有效性和安全性的研究。
