Karachalios G N, Donas G, Tsimiklis S, Stathakakis V
Department of Medicine, Kalamata General Hospital, Greece.
Int J Clin Pharmacol Ther Toxicol. 1988 Jul;26(7):351-5.
The effects and safety of using sublingually nifedipine 10-20 mg as acute antihypertensive treatment were evaluated in 108 patients with hypertensive emergencies or urgency without intensive care monitoring. Before treatment, mean systolic blood pressure was 220 +/- 28 mmHg, mean diastolic blood pressure was 125 +/- 15 mmHg and mean arterial pressure was 155 +/- 14 mmHg. Administration of 10 mg of sublingual nifedipine reduced the blood pressure within 10 min and produced a peak effect level between 30 to 40 min. Blood pressure decreased significantly to a mean 155 +/- 20 and 92 +/- 14 mmHg systolic and diastolic blood pressure, respectively. Minimal adverse effects was observed. Five patients, required additional therapy with other antihypertensive drugs. Heart rate increased from 74 +/- 10 to 84 +/- 10 beats per min. The response to nifedipine correlated with the blood pressure value prior to treatment, but did not correlate with age or the type of hypertensive emergency. These results indicate that nifedipine administered sublingually is a simple, effective, and safe agent for treating hypertensive emergencies, especially for the patients in whom intensive care monitoring cannot be guaranteed.
在108例未进行重症监护监测的高血压急症或亚急症患者中，评估了舌下含服10 - 20 mg硝苯地平作为急性降压治疗的效果和安全性。治疗前，平均收缩压为220±28 mmHg，平均舒张压为125±15 mmHg，平均动脉压为155±14 mmHg。舌下含服10 mg硝苯地平可在10分钟内降低血压，并在30至40分钟内达到峰值效应水平。血压显著下降，收缩压和舒张压分别平均降至155±20 mmHg和92±14 mmHg。观察到的不良反应最小。5例患者需要加用其他降压药物治疗。心率从74±10次/分钟增加到84±10次/分钟。对硝苯地平的反应与治疗前的血压值相关，但与年龄或高血压急症类型无关。这些结果表明，舌下含服硝苯地平是治疗高血压急症的一种简单、有效且安全的药物，尤其适用于无法保证进行重症监护监测的患者。
