Pinggera D, Geiger P, Thomé C
Universitätsklinik für Neurochirurgie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.
Nervenarzt. 2023 Oct;94(10):960-972. doi: 10.1007/s00115-023-01546-9. Epub 2023 Sep 7.
Traumatic brain injury (TBI) describes parenchymal brain damage caused by external forces to the head. It has a massive personal and socioeconomic impact, as it is a disease with high morbidity and mortality. Both young and old people are affected, as a result of traffic or sports accidents as well as due to falls at home. The term TBI encompasses various clinical pictures, differing considerably in cause, prognosis and therapy. What they all have in common is the pathophysiological cascade that develops immediately after the initial trauma and which can persist for several days and weeks. In this phase, medical treatment, whether surgical or pharmacological, attempts to reduce the consequences of the primary damage. The aim is to maintain adequate cerebral perfusion pressure and to reduce intracranial pressure.
创伤性脑损伤(TBI)是指头部受到外力作用导致的脑实质损伤。它对个人和社会经济有着巨大影响,因为这是一种发病率和死亡率都很高的疾病。年轻人和老年人都会受到影响,原因包括交通或运动事故以及在家中跌倒。TBI这一术语涵盖了各种临床表现,其病因、预后和治疗方法差异很大。它们的共同之处在于初始创伤后立即发生的病理生理级联反应,这种反应可能持续数天甚至数周。在此阶段,无论是手术治疗还是药物治疗,都旨在减轻原发性损伤的后果。目标是维持足够的脑灌注压并降低颅内压。