Mass General Brigham Inc, Boston, Massachusetts 02114, United States.
Department of Chemistry, Institute for Psychedelics and Neurotherapeutics, Department of Biochemistry & Molecular Medicine, School of Medicine, University of California Davis, Davis, California 95616, United States.
ACS Chem Neurosci. 2023 Sep 20;14(18):3288-3290. doi: 10.1021/acschemneuro.3c00526. Epub 2023 Sep 7.
Neuroplasticity is a term that is increasingly permeating mainstream discourse and being used by the popular press to simplify descriptions of how the brain changes in response to stimuli such as exercise, sleep, food, drugs of abuse, and medicines, among others. However, it is a complex, multifaceted concept representing a continuum connecting molecular, cellular, and circuit-level changes and their effects on human behavior. In this Viewpoint, we examine neuroplasticity from several perspectives to construct a holistic view of this ambiguous term. By engaging experts across various scientific disciplines, we attempt to provide an easy entry point to the concept of neuroplasticity for readers of . By highlighting how neuroplasticity changes in both health and disease, we demonstrate that the concept is applicable to both adaptive and maladaptive responses to stimuli, underscoring its significance in chemical neuroscience.
神经可塑性是一个术语，它越来越渗透到主流话语中，并被大众媒体用来简化描述大脑如何响应刺激（如运动、睡眠、食物、滥用药物和药物等）而发生变化。然而，它是一个复杂的、多方面的概念，代表着一个连接分子、细胞和电路水平变化及其对人类行为影响的连续体。在本观点中，我们从几个角度来考察神经可塑性，以构建对这个模糊术语的整体看法。通过邀请各个科学领域的专家参与，我们试图为. 的读者提供一个简单的切入点来了解神经可塑性的概念。通过强调神经可塑性在健康和疾病中的变化，我们证明了这个概念适用于对刺激的适应性和不良适应性反应，强调了它在化学生物学中的重要性。
