Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China.
Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China.
J Physiol Biochem. 2023 Nov;79(4):719-730. doi: 10.1007/s13105-023-00982-0. Epub 2023 Sep 7.
Sonic hedgehog (SHH) signaling is vital for cell differentiation and proliferation during embryonic development, yet its role in cardiac, cerebral, and vascular pathophysiology is under debate. Recent studies have demonstrated that several compounds of SHH signaling regulate ion channels, which in turn affect the behavior of target cells. Some of these ion channels are involved in the cardio-cerebrovascular system. Here, we first reviewed the SHH signaling cascades, then its interaction with ion channels, and their impact on cardio-cerebrovascular diseases. Considering the complex cross talk of SHH signaling with other pathways that also affect ion channels and their potential impact on the cardio-cerebrovascular system, we highlight the necessity of thoroughly studying the effect of SHH signaling on ion homeostasis, which could serve as a novel mechanism for cardio-cerebrovascular diseases. Activation of SHH signaling influence ion channels activity, which in turn influence ion homeostasis, membrane potential, and electrophysiology, could serve as a novel strategy for cardio-cerebrovascular diseases.
sonic 刺猬 (SHH) 信号对于胚胎发育过程中的细胞分化和增殖至关重要，但它在心脏、大脑和血管病理生理学中的作用仍存在争议。最近的研究表明，SHH 信号的几种化合物调节离子通道，进而影响靶细胞的行为。其中一些离子通道参与了心肺血管系统。在这里，我们首先回顾了 SHH 信号通路，然后讨论了它与离子通道的相互作用及其对心肺血管疾病的影响。鉴于 SHH 信号与其他也影响离子通道并可能对心肺血管系统产生影响的途径的复杂串扰，我们强调了彻底研究 SHH 信号对离子动态平衡影响的必要性，这可能是心肺血管疾病的一种新机制。SHH 信号的激活影响离子通道的活性，进而影响离子动态平衡、膜电位和电生理学，这可能成为心肺血管疾病的一种新策略。
