Alvarado J A, Yun A J, Murphy C G
Arch Ophthalmol. 1986 Oct;104(10):1517-28. doi: 10.1001/archopht.1986.01050220111038.
The juxtacanalicular (JXT) tissue was evaluated in 64 specimens from 36 nonglaucomatous normal persons and 28 specimens from 26 patients with primary open angle glaucoma (POAG). Morphometry was performed on more than 2000 electron micrographs taken from the entire JXT region of each of the 64 specimens studied. The concentration of three electron-dense materials (EDMs) believed to obstruct the JXT tissue in POAG was measured using precise and reproducible morphometric methods. There is a great deal of variability in the EDM concentration, but we could still measure a significant increase in EDM of about 0.2% each year in normal specimens. Specimens from patients with POAG who are younger than 40 years of age have an EDM concentration similar to that in normal specimens. After the approximate age of 40 years, a significant difference is observed in the EDM concentration between nonglaucomatous and POAG specimens. This difference represents an average increase of 23% in POAG. Such a difference is probably too small to account for the decrease in outflow facility characteristic of POAG.
对36名非青光眼正常人的64个标本和26例原发性开角型青光眼（POAG）患者的28个标本中的小梁网组织进行了评估。对所研究的64个标本中每个标本的整个小梁网组织区域拍摄的2000多张电子显微照片进行了形态计量学分析。使用精确且可重复的形态计量学方法测量了三种据信会阻塞POAG中小梁网组织的电子致密物质（EDM）的浓度。EDM浓度存在很大差异，但我们仍可测量到正常标本中EDM每年约有0.2%的显著增加。年龄小于40岁的POAG患者的标本中EDM浓度与正常标本中的相似。在大约40岁之后，非青光眼和POAG标本之间的EDM浓度出现了显著差异。这种差异在POAG中平均增加了23%。这样的差异可能太小，无法解释POAG特征性的房水流出易度降低。
