Ranney R E, Oppermann J A
J Environ Pathol Toxicol. 1979 Mar-Apr;2(4):979-85.
Aspartame (3-amino-N-(alpha-carboxyphenethyl) succinamic acid, methyl ester; the methyl ester of aspartylphenylalanine, SC-18862) is hydrolyzed in the gut to yield aspartic acid, phenylalanine, and methanol. This review of the literature describes the metabolic paths followed by aspartate in its conversion to CO2 or its incorporation into body constituents. About 70 percent of 14C from [asp-14C]-aspartame is converted in the monkey to 14CO2. Some of the aspartate is converted at the intestinal mucosal level to alanine by decarboxylation. This amino acid may be oxidized to CO2 by entering the tricarboxylic acid cycle via pyruvate and acetyl CoA. In addition, transamination of aspartate to oxaloacetate permits this product also to enter the tricarboxylic acid cycle. Aspartate may also be incorporated into body constitutents such as other amino acids, proteins, pyrimidines, asparagine, and N-acetylaspartic acid. It is concluded that the aspartate moiety of aspartame is metabolized in a manner similar to that of dietary aspartic acid.
阿斯巴甜（3-氨基-N-（α-羧基苯乙基）琥珀酰胺酸甲酯；天冬氨酰苯丙氨酸甲酯，SC-18862）在肠道中水解，生成天冬氨酸、苯丙氨酸和甲醇。本文献综述描述了天冬氨酸转化为二氧化碳或并入身体成分所遵循的代谢途径。在猴子体内，[天冬氨酸-14C] -阿斯巴甜中约70%的14C转化为14CO2。部分天冬氨酸在肠黏膜水平通过脱羧作用转化为丙氨酸。该氨基酸可通过丙酮酸和乙酰辅酶A进入三羧酸循环而被氧化为二氧化碳。此外，天冬氨酸转氨生成草酰乙酸，使该产物也能进入三羧酸循环。天冬氨酸还可能并入身体成分，如其他氨基酸、蛋白质、嘧啶、天冬酰胺和N-乙酰天冬氨酸。得出的结论是，阿斯巴甜的天冬氨酸部分的代谢方式与膳食中天冬氨酸的代谢方式相似。
