Stegink L D, Filer L J, Baker G L
J Nutr. 1977 Oct;107(10):1837-45. doi: 10.1093/jn/107.10.1837.
Aspartame is a dipeptide (L-aspartyl-L-phenylalanyl-methyl ester) with a sweeting potential 180 to 200 times that of sucrose. Questions have been raised about potential toxic effects of its constituent amino acids, aspartate and phenylalanine when the compound is ingested in large amounts. Plasma and erythrocyte amino acid levels were measured in 12 normal subjects after administration of either Aspartame (34 mg/kg) or equimolar quantities of aspartate (13 mg/kg) in a crossover design. No changes in either plasma or erythrocyte aspartate levels were noted at any time after either Aspartame or aspartate ingestion. Plasma phenylalanine levels decrease slightly after aspartate loading, and increased from fasting levels (4.9 +/- 1 mumoles/100 ml) to 10.7 +/- 1.9 mumoles/100 ml about 45 to 60 minutes after Aspartame loading. Phenylalanine levels returned to baseline by 4 hours. Erythrocyte phenylalanine levels showed similar changes.
阿斯巴甜是一种二肽（L-天冬氨酰-L-苯丙氨酸甲酯），其甜度约为蔗糖的180至200倍。当大量摄入该化合物时，其组成氨基酸天冬氨酸和苯丙氨酸的潜在毒性作用引发了一些问题。采用交叉设计，对12名正常受试者给予阿斯巴甜（34毫克/千克）或等摩尔量的天冬氨酸（13毫克/千克）后，测定其血浆和红细胞氨基酸水平。摄入阿斯巴甜或天冬氨酸后，在任何时间均未观察到血浆或红细胞中天冬氨酸水平的变化。摄入天冬氨酸后，血浆苯丙氨酸水平略有下降，而摄入阿斯巴甜后约45至60分钟，血浆苯丙氨酸水平从空腹水平（4.9±1微摩尔/100毫升）升至10.7±1.9微摩尔/100毫升。4小时后苯丙氨酸水平恢复至基线。红细胞苯丙氨酸水平也出现了类似变化。
