VerStrate Cheryl Ann, Mahon Suzanne M
Grand Valley State University.
Saint Louis University.
Clin J Oncol Nurs. 2023 Jul 20;27(4):380-388. doi: 10.1188/23.CJON.380-388.
The use of direct-to-consumer genomic testing (DTCGT) is increasing, but this testing may not be comprehensive and may lack clinical validity and utility. The ethical constructs of beneficence, nonmaleficence, justice, and autonomy provide a framework for coordinating the care of patients and their families.
This article provides an overview of the DTCGT process and reviews the ethical implications that affect clinical care.
A review of the literature was conducted using the following key words: genetics/genomics and direct-to-consumer testing. Common themes were identified, including test types, regulatory standards, marketing practices, ethics, privacy, and nursing implications.
An increased awareness of the clinical and ethical consequences of DTCGT is needed among healthcare providers and the general population. Oncology nurses can assist patients in navigating the field of genomics through consistent and comprehensive risk assessment, patient education about the risks and benefits of DTCGT, and referral to genomics professionals when appropriate.
直接面向消费者的基因检测（DTCGT）的使用正在增加，但这种检测可能并不全面，可能缺乏临床有效性和实用性。行善、不伤害、公正和自主的伦理观念为协调患者及其家属的护理提供了一个框架。
本文概述了DTCGT过程，并综述了影响临床护理的伦理问题。
使用以下关键词对文献进行综述：遗传学/基因组学和直接面向消费者的检测。确定了常见主题，包括检测类型、监管标准、营销实践、伦理、隐私和护理问题。
医疗保健提供者和普通人群需要提高对DTCGT临床和伦理后果的认识。肿瘤学护士可以通过持续和全面的风险评估、对DTCGT风险和益处的患者教育以及在适当的时候转介给基因组学专业人员，帮助患者在基因组学领域中导航。
