Cazeau Naomi, Rodriguez Stephany L
Memorial Sloan Kettering Cancer Center.
University of California, San Francisco.
Clin J Oncol Nurs. 2023 Jul 20;27(4):397-403. doi: 10.1188/23.CJON.397-403.
Acute graft-versus-host disease (aGVHD) is a significant complication for patients who receive allogeneic stem cell transplantation. Patients whose aGVHD is refractory to corticosteroids face additional complications.
This article provides foundational knowledge on steroid-refractory (SR) aGVHD, current treatment options, and related supportive care.
Therapies for patients with SR aGVHD are summarized, along with supportive care recommendations and a review of related nursing considerations.
Current treatment and research on SR aGVHD offer opportunities for improved clinical outcomes for these patients. Nursing knowledge of the pathophysiology, treatment, and supportive care for patients with SR aGVHD is integral to the provision of optimal nursing care for a complex population of patients.
急性移植物抗宿主病（aGVHD）是接受异基因干细胞移植患者的一种严重并发症。对皮质类固醇难治的aGVHD患者面临更多并发症。
本文提供关于类固醇难治性（SR）aGVHD的基础知识、当前的治疗选择及相关支持性护理。
总结了SR aGVHD患者的治疗方法、支持性护理建议及相关护理考量的综述。
目前对SR aGVHD的治疗和研究为改善这些患者的临床结局提供了机会。护士了解SR aGVHD患者的病理生理学、治疗及支持性护理知识，对于为这一复杂患者群体提供最佳护理至关重要。
