Yu V Y, Wong P Y, Bajuk B, Szymonowicz W
Aust Paediatr J. 1986 Aug;22(3):189-92. doi: 10.1111/j.1440-1754.1986.tb00221.x.
Eighty (32%) of 249 infants weighing less than 1000 g at birth developed pulmonary interstitial emphysema (PIE); its incidence was 42% in infants at 500-799 g, 29% at 800-899 g and 20% at 900-999 g. Fifty-five per cent occurred in the first 24 h and 43% were associated with other forms of air leak. The incidence and mortality of PIE did not improve between 1977 and 1984. The mortality rates in infants with or without PIE were not significantly different in the first 4 years of the study period (53% vs 45%). As the mortality improved in infants without PIE during the second 4 years, the difference in mortality rates in infants with or without PIE became significant (68% vs 29%). PIE continues to be associated with serious mortality and morbidity in extremely low birthweight infants. Effective measures to prevent PIE are required before further improvement in their outcome can be achieved.
249例出生体重低于1000克的婴儿中，有80例（32%）发生了肺间质气肿（PIE）；其发病率在体重500 - 799克的婴儿中为42%，800 - 899克的婴儿中为29%，900 - 999克的婴儿中为20%。55%发生在出生后24小时内，43%与其他形式的气体泄漏有关。1977年至1984年间，PIE的发病率和死亡率没有改善。在研究的前4年中，有或没有PIE的婴儿死亡率没有显著差异（53%对45%）。随着后4年中无PIE婴儿的死亡率有所改善，有或没有PIE的婴儿死亡率差异变得显著（68%对29%）。在极低出生体重婴儿中，PIE仍然与严重的死亡率和发病率相关。在极低出生体重婴儿的预后得到进一步改善之前，需要采取有效的措施来预防PIE。
