Yu V Y, Wong P Y, Bajuk B, Szymonowicz W
Arch Dis Child. 1986 Mar;61(3):239-41. doi: 10.1136/adc.61.3.239.
The incidence of pulmonary air leak in 230 infants with a birth weight of 500-999 g who were ventilated was 41%. Pulmonary interstitial emphysema occurred in 35%, pneumothorax in 20%, pneumomediastinum in 3%, and pneumopericardium in 2%. The survival rates in those with or without pulmonary air leak were not significantly different in the first four years of the study period (46% v 53%). As the survival improved in infants without air leak during the second four years the difference in survival rates in infants with or without air leak became significant (30% v 71%). Effective measures of preventing pulmonary air leak are required before further improvement in the outcome of these extremely low birthweight infants can be achieved.
230例出生体重500 - 999克且接受通气治疗的婴儿中，肺漏气的发生率为41%。肺间质气肿发生率为35%，气胸发生率为20%，纵隔气肿发生率为3%，心包积气发生率为2%。在研究的前四年中，有或无肺漏气婴儿的存活率无显著差异（46%对53%）。随着后四年中无漏气婴儿存活率的提高，有或无漏气婴儿的存活率差异变得显著（30%对71%）。在这些极低出生体重婴儿的预后得到进一步改善之前，需要采取有效的预防肺漏气措施。
