Abo Al-Azayem Salsabil, Kishk Nirmeen A, Shamloul Reham, Attia Abeer, Elsayed Radwa M, Magdy Rehab
Department of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Epilepsy Behav. 2023 Oct;147:109421. doi: 10.1016/j.yebeh.2023.109421. Epub 2023 Sep 6.
Available data about sexual-related problems among Egyptian women with epilepsy (WWE) are scarce. Hence, this work aimed to study the pattern and predictors of sexual dysfunction in a sample of Egyptian WWE.
In this cross-sectional study, sexually active WWE and age and years of marriage-matched healthy controls were included. The Female Sexual Function Index questionnaire (FSFI) was used to assess sexual function in both groups.
In the patient group (n = 142), the median age was 33 (28-39), whereas the median age of the control group (n = 142) was 33.5 (28-36). Women with epilepsy had significantly lower desire, arousal, pain, and FSFI-total scores than the control group (P = 0.001, 0.001, 0.023, 0.008, respectively). There was a significant difference between the FSFI-total score of women on polytherapy and those on monotherapy (P = 0.042), as well as between those on enzyme-inducing ASMs and those on ASMs that did not affect P450 (P = 0.032). Seizure frequency in the last three months was negatively correlated with scores of desire, arousal, lubrication, orgasm, and satisfaction (P 0.047, 0.02, 0.009, 0.013, 0.046, respectively). By multiple backward linear regression models, age, and seizure frequency were the significant predictors of the FSFI-total score (B -0.219, -0.33, respectively).
The pattern of sexual dysfunction among Egyptian WWE is characterized by reduced sexual desire, arousal deficits, and sexual-related pain. Seizure frequency, epilepsy duration, enzyme-inducing medications, and multiple anti-seizure medications (ASMs) may adversely affect WWE's sexual health. The only factor that could predict higher sexual dysfunction in WWE was higher seizure frequency.
关于埃及癫痫女性（WWE）性相关问题的现有数据匮乏。因此，本研究旨在探讨埃及WWE样本中性功能障碍的模式及预测因素。
在这项横断面研究中，纳入了有性活动的WWE以及年龄和婚姻年限匹配的健康对照。使用女性性功能指数问卷（FSFI）评估两组的性功能。
患者组（n = 142）的中位年龄为33岁（28 - 39岁），而对照组（n = 142）的中位年龄为33.5岁（28 - 36岁）。癫痫女性的性欲、性唤起、性交疼痛及FSFI总分显著低于对照组（分别为P = 0.001、0.001、0.023和0.008）。联合治疗的女性与单药治疗的女性在FSFI总分上存在显著差异（P = 0.042），诱导酶的抗癫痫药物使用者与不影响P450的抗癫痫药物使用者之间也存在显著差异（P = 0.032）。过去三个月的癫痫发作频率与性欲、性唤起、润滑、性高潮及满意度得分呈负相关（分别为P 0.047、0.02、0.009、0.013和0.046）。通过多元向后线性回归模型，年龄和癫痫发作频率是FSFI总分的显著预测因素（B分别为 - 0.219和 - 0.33）。
埃及WWE中性功能障碍的模式表现为性欲降低、性唤起不足及性相关疼痛。癫痫发作频率、癫痫病程、诱导酶的药物及多种抗癫痫药物（ASMs）可能对WWE的性健康产生不利影响。唯一能预测WWE更高性功能障碍的因素是更高的癫痫发作频率。
