天门冬氨酸氨基转移酶/丙氨酸氨基转移酶（De Ritis）比值对嵌顿性腹股沟疝患者肠坏死的预测价值。
Predictivity of aspartate aminotransferase to alanine aminotransferase (De Ritis) ratio for detecting bowel necrosis in incarcerated inguinal hernia patients.
机构信息
Department of General Surgery, Adana City Research and Training Hospital, Adana.
Department of General Surgery, Balıklıgol Government Hospital, Sanlıurfa. Turkey.
出版信息
Cir Cir. 2023;91(4):494-500. doi: 10.24875/CIRU.22000273.
PURPOSE
Early diagnosis of necrotic bowel segment resulting from incarcerated inguinal hernia (IIH) is crucial for reducing morbidity and mortality. The aim of this study was to investigate the efficacy of the De Ritis ratio (DRR), also known as the ratio of aspartate aminotransferase to alanine aminotransferase, as a biomarker for intestinal necrosis.
METHODS
This retrospective study included 132 patients who underwent emergency surgery for IIH. Patients were divided into two groups: those who underwent bowel resection for necrosis (Group 1) and those who did not (Group 2). Patients' demographic and clinical data were recorded. Using laboratory test results, DRR, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and lymphocyte-to-CRP ratio (LCR) were calculated.
RESULTS
The morbidity and mortality rates and the length of stay for Group 1 were statistically significantly different (p < 0.0001). The DRR, NLR, PLR, LMR, and LCR values of the same group were also significantly different (p < 0.05).
CONCLUSION
DRR can be used as a biomarker for early diagnosis of bowel necrosis in patients with IIH.
目的
早期诊断腹股沟疝嵌顿导致的坏死肠段对于降低发病率和死亡率至关重要。本研究旨在探讨 De Ritis 比值（DRR）作为肠坏死标志物的有效性，DRR 也称为天门冬氨酸氨基转移酶与丙氨酸氨基转移酶的比值。
方法
本回顾性研究纳入了 132 例因 IIH 而行急诊手术的患者。患者分为两组：发生肠坏死而行肠切除术的患者（组 1）和未发生肠坏死的患者（组 2）。记录患者的人口统计学和临床数据。利用实验室检测结果，计算 DRR、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和淋巴细胞与 CRP 比值（LCR）。
结果
组 1 的发病率、死亡率和住院时间有显著差异（p < 0.0001）。同一组的 DRR、NLR、PLR、LMR 和 LCR 值也有显著差异（p < 0.05）。
结论
DRR 可作为 IIH 患者肠坏死早期诊断的标志物。
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