Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Molecular Pharmacology & Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Neuron. 2023 Sep 6;111(17):2620-2622. doi: 10.1016/j.neuron.2023.08.013.
After repeatedly failing to get out of a stressful, uncontrollable environment, mice switch from escape behavior to inactivity. In this issue of Neuron, Li et al. identify a circuit involving noradrenergic projections from the locus coeruleus to GABAergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior.
在反复未能摆脱压力环境后，老鼠会从逃避行为转变为不活动状态。在本期《神经元》杂志中，李等人发现了一个涉及蓝斑核到眶额皮质 GABA 能投射神经元的去甲肾上腺素能投射的回路，该回路参与了这种适应性行为。
