铜掺杂碳点作为模拟纳米酶用于生物样品中吗啡的比色检测。
Cu, I-doped carbon dots as simulated nanozymes for the colorimetric detection of morphine in biological samples.
机构信息
Key Laboratory of Smart Drugs Control, Ministry of Education, Kunming, 650223, China; Yunnan Key Laboratory of Smart Drugs Control, Kunming, 650223, China; Yunnan Police College, Kunming, 650223, China.
Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicina Endophytes, Yunnan Minzu University, Kunming, 650500, China.
出版信息
Anal Biochem. 2023 Nov 1;680:115313. doi: 10.1016/j.ab.2023.115313. Epub 2023 Sep 9.
As newly developed synthetic enzymes with exceptional catalytic capabilities and outstanding stability, nanozymes have drawn considerable interest in the realm of sensing. Using a simple hydrothermal process, iodine and copper-doped carbon dots (Cu,I-CDs) with simulated enzymes were fabricated in the current investigation. Cu,I-CDs demonstrate peroxidase-mimicking function together with high catalytic effectiveness due to aforementioned features. This led to generation of a colorimetric sensor for quick and accurate quantitative assessment of morphine (MOR). The outcomes showed the method's usefulness for the colorimetric detection of MOR. The linear range for MOR detection is 0.25-25 μg/mL having a reduced detection limit of 64 ng/mL. This sensor's successful use in the analysis of MOR in biological material is more noteworthy.
作为具有出色催化能力和卓越稳定性的新型合成酶，纳米酶在传感领域引起了相当大的兴趣。本研究采用简单的水热法制备了具有模拟酶功能的碘和铜掺杂碳点（Cu，I-CDs）。由于上述特性，Cu，I-CDs 表现出过氧化物酶模拟功能和高催化效率。这导致了一种比色传感器的产生，可快速准确地定量评估吗啡（MOR）。结果表明该方法可用于 MOR 的比色检测。MOR 的检测线性范围为 0.25-25μg/mL，检测下限为 64ng/mL。更值得注意的是，该传感器成功地用于生物材料中 MOR 的分析。
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