Hospices Civils de Lyon - Centre de soins palliatifs - Hôpital Lyon Sud, Pierre-Bénite, France.
Claude Bernard Université Lyon 1 - EA3738 -Centre pour l'innovation en cancérologie de Lyon, Faculty Lyon Sud, Oullins, France.
Sci Rep. 2023 Sep 7;13(1):14750. doi: 10.1038/s41598-023-42047-8.
The peritoneal surface malignancy (PSM) is an advanced disease, the prognosis of which has been radically improved since the development of cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC). These procedures are associated with many complications. However, very few data are available regarding the psychiatric morbidities that might occur. The present study assessed the epidemiology of depressive mood and anxiety during the 6 months following the procedure. The analysis of a prospective cohort that included patients who underwent CRS with or without HIPEC between December 2016 and December 2019 was performed. A total of 115 patients were included. During the 6-months follow-up, the mean (SD) Hospital Anxiety and Depression Scale -D (HADS-D) score was 7.8 (48) and a significant increase compared with the pre-operative period (t(49) = - 4.36, p < 0.005) was found. Thirty-seven patients (32%) had a HADS-D score higher than 7. The incidence of a HADS-D score higher than 7 during the follow-up was 0.05 patient per patient-month. Anxiety and the overall mental disorders intensity scores also increased. The results showed an important increase of mental disorders and their intensity during the 6-months following a CRS with or without HIPEC.
腹膜表面恶性肿瘤（PSM）是一种晚期疾病，自从开展细胞减灭术（CRS）联合或不联合腹腔内热化疗（HIPEC）以来，其预后得到了显著改善。这些手术会带来许多并发症。然而，关于可能发生的精神疾病方面的数据却非常有限。本研究评估了术后 6 个月内抑郁情绪和焦虑的流行病学。对 2016 年 12 月至 2019 年期间接受 CRS 联合或不联合 HIPEC 的患者进行前瞻性队列分析。共纳入 115 例患者。在 6 个月的随访期间，平均（SD）医院焦虑和抑郁量表 -D（HADS-D）评分为 7.8（48），与术前相比显著增加（t（49）=-4.36，p<0.005）。37 例患者（32%）HADS-D 评分大于 7。在随访期间，HADS-D 评分大于 7 的发生率为 0.05 例/患者-月。焦虑和整体精神障碍严重程度评分也有所增加。结果表明，在接受 CRS 联合或不联合 HIPEC 治疗后的 6 个月内，精神障碍及其严重程度显著增加。
