以草履虫为模型评估化学诱导的对水生生物的光毒性。

Evaluation of chemically-induced phototoxicity to aquatic organism using Paramecium as a model.

作者信息

Joshi P C, Misra R B

出版信息

Biochem Biophys Res Commun. 1986 Aug 29;139(1):79-84. doi: 10.1016/s0006-291x(86)80082-1.

Abstract

Phototoxicity evaluation using Paramecium aurelia as a model revealed that 4 out of 21 pesticides produced lethal toxicity to cells. Four commonly used synthetic dyes (bromophenol blue, rose bengal, benzanthrone and methylene blue) also exhibited toxicity. Well known phototoxic agents like hematoporphyrin, riboflavin, and anthracene produced positive phototoxic response. Psoralen, a DNA cross-linking agent, also produced phototoxicity to the cells. The results clearly demonstrate that the synergistic action of chemical agents and sunlight produce lethal effects to aquatic organism.

摘要

以草履虫为模型进行的光毒性评估显示，21种农药中有4种对细胞产生致命毒性。四种常用合成染料（溴酚蓝、孟加拉玫瑰红、苯并蒽酮和亚甲蓝）也表现出毒性。知名的光毒性剂如血卟啉、核黄素和蒽产生了阳性光毒性反应。补骨脂素，一种DNA交联剂，也对细胞产生光毒性。结果清楚地表明，化学剂与阳光的协同作用对水生生物产生致命影响。