Department of Orthopedics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214000, China.
Department of Orthopedics, Taicang Shaxi People's Hospital, Taicang, 215400, China.
BMC Med Genomics. 2023 Sep 7;16(1):212. doi: 10.1186/s12920-023-01650-4.
The correlation between smoking and alcohol consumption and the development of Dupuytren's disease (DD) has been acknowledged. However, the definitive causal relationship between these two factors and DD remains elusive. In order to establish a causal connection, we employed the two-sample Mendelian randomization method to evaluate the relationship between smoking and alcohol consumption and DD.
Based on publicly available genome-wide association studies (GWAS), two-sample univariate MR analyses were performed to assess the causal effects of drinks per week, cigarettes per day, smoking initiation, age of initiation, and smoking cessation on DD. We used inverse variance weighted (IVW) to generate the primary results for the MR analysis. Furthermore, we performed sensitivity MR analyses based on various methods to assess the robustness of estimations. Bidirectional MR analyses were used to study the interaction between smoking and alcohol consumption. Multivariate MR analyses were used to obtain independent causal effects of smoking or drinking on DD.
Our two-sample MR, which was predominately based on IVW, revealed a causal relationship between drinks per week and DD (OR = 2.948, 95%CI: 1.746-4.975, P = 5.16E-05). In addition, there is no causal association between cigarettes per day, smoking initiation, age of initiation, smoking cessation and DD. Similar conclusions were reached by other MR methods. The results of the bidirectional MR analyses showed that the causal relationships between age of initiation and drinks per week were robust and significant. Multivariate MR results indicated that the causal effect of alcohol consumption on DD was independent of smoking.
Our Mendelian Randomization study indicated that there is a causality between drinking alcohol and DD, but no such causality was found between smoking and DD. This is the first study to prove that drinking alcohol could cause DD. This could help people who are trying to prevent DD from happening in the first place.
吸烟和饮酒与掌腱膜挛缩症（Dupuytren's disease，DD）的发生之间存在相关性。然而，这两个因素与 DD 之间的确切因果关系仍难以确定。为了建立因果关系，我们采用两样本孟德尔随机化方法来评估吸烟和饮酒与 DD 之间的关系。
基于公开的全基因组关联研究（genome-wide association studies，GWAS），我们进行了两样本单变量 MR 分析，以评估每周饮酒量、每天吸烟量、吸烟起始年龄、起始年龄和戒烟与 DD 之间的因果关系。我们使用逆方差加权（inverse variance weighted，IVW）生成 MR 分析的主要结果。此外，我们还基于各种方法进行敏感性 MR 分析，以评估估计的稳健性。双向 MR 分析用于研究吸烟和饮酒之间的相互作用。多变量 MR 分析用于获得吸烟或饮酒对 DD 的独立因果效应。
我们的两样本 MR 主要基于 IVW，结果表明每周饮酒量与 DD 之间存在因果关系（OR=2.948，95%CI：1.746-4.975，P=5.16E-05）。此外，每天吸烟量、吸烟起始、起始年龄和戒烟与 DD 之间不存在因果关系。其他 MR 方法也得出了类似的结论。双向 MR 分析的结果表明，起始年龄与每周饮酒量之间的因果关系是稳健且显著的。多变量 MR 结果表明，饮酒对 DD 的因果效应独立于吸烟。
我们的孟德尔随机化研究表明，饮酒与 DD 之间存在因果关系，但吸烟与 DD 之间不存在这种因果关系。这是首个证明饮酒会导致 DD 的研究。这有助于人们从一开始就预防 DD 的发生。
